Caragana sinicaCaragana sinica (simplified Chinese: 金鹊根; traditional Chinese: 金鵲根; pinyin: jīnquègēn) is a species belonging to the genus Caragana. Caragana sinica is known to produce the stilbenoid trimers α-viniferin, showing acetylcholinesterase inhibitory activity, and miyabenol C, a protein kinase C inhibitor and two stilbene tetramers kobophenol A, and carasinol B. ReferencesWikispecies has information related to Caragana sinica.
Carasinol BCarasinol B is a stilbenoid tetramer found in Caragana sinica (Chinese : Jin Que-gen). Acid-catalyzed epimerization of kobophenol A to carasinol B can be performed in vitro.
TetramerA tetramer () (, "four" + , "parts") is an oligomer formed from four monomers or subunits. The associated property is called tetramery. An example from inorganic chemistry is titanium methoxide with the empirical formula Ti(OCH3)4, which is tetrameric in solid state and has the molecular formula Ti4(OCH3)16. An example from organic chemistry is kobophenol A, a substance that is formed by combining four molecules of resveratrol.
Carex folliculataCarex folliculata, the northern long sedge, is a species of flowering plant in the family Cyperaceae. It is native to eastern Canada (and Saint Pierre and Miquelon), and the eastern United States (but in the southeast it is confined to the Appalachians). A clumping perennial reaching 150 cm (5 ft) but usually shorter, it has broad, yellowish-green leaves.
ResveratrolResveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol or polyphenol and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.StilbenoidStilbenoids are hydroxylated derivatives of stilbene. They have a C6–C2–C6 structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
In vitroIn vitro (meaning in glass, or in the glass) studies are performed with cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates.
AcetylcholinesteraseMore reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 7: 100.89 – 100.9 MbChr 5: 137.29 – 137.29 MbPubMed searchWikidataAcetylcholinesterase(AChE)acetylcholine acetylhydrolase, also known as AChase or acetylhydrolase, is the primary type of cholinesterase in the body, coded for in the human by the gene ACHE.
Miyabenol CMiyabenol C is a stilbenoid. It is a resveratroltrimer. It is found in Vitis vinifera (grape), in Foeniculi fructus (fruit of Foeniculum vulgare), in Caragana sinica. It shows protein kinase C inhibitor activity.
Α-Viniferinα-Viniferin is a stilbene trimer. It can be isolated from Caragana chamlagu and from Caragana sinica and from the stem bark of Dryobalanops aromatica. It is also present in relation to resistance to Botrytis cinerea and Plasmopara viticola in Vitis vinifera and Vitis riparia. It has been shown to inhibit acetylcholinesterase.
CorydalineCorydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo. Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It also has diverse biological activities. It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM), antiallergic, antinociceptive, and gastric emptying activities.*As an Amazon Associate I earn from qualifying purchases.