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Intestinal gland

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In histology, an intestinal gland (also crypt of Lieberkühn and intestinal crypt) is a gland found in between villi in the intestinal epithelial lining of the small intestine and large intestine (or colon). The glands and intestinal villi are covered by epithelium, which contains multiple types of cells: enterocytes (digesting and absorbing nutrients and electrolytes), goblet cells (secreting mucus), enteroendocrine cells (secreting hormones), cup cells, tuft cells, and at the base of the gland, Paneth cells (secr…

Intestinal epitheliumIntestinal epitheliumThe intestinal epithelium is the single cell layer that forms the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. Composed of simple columnar epithelium its main functions are absorption, and secretion. Useful substances are absorbed into the body, and the entry of harmful substances is restricted. Secretions include mucins, and peptides.Small intestineSmall intestineThe small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from food takes place. It lies between the stomach and large intestine, and receives bile and pancreatic juice through the pancreatic duct to aid in digestion. The small intestine is about 6.5 metres (21 feet) long and folds many times to fit in the abdomen.Goblet cellGoblet cellGoblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress. The term goblet refers to the cell's goblet-like shape.Large intestineLarge intestineThe large intestine, also known as the large bowel, is the last part of the gastrointestinal tract and of the digestive system in tetrapods. Water and salts are absorbed here and the remaining waste material is stored in the rectum as feces before being removed by defecation. Although it is shorter than the small intestine, it is called the large intestine because it is wider in diameter.EnterocyteEnterocyteEnterocytes, or intestinal absorptive cells, are simple columnarepithelial cells which line the inner surface of the small and large intestines. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase its surface area. This facilitates transport of numerous small molecules into the enterocyte from the intestinal lumen. These include broken down proteins, fats, and sugars, as well as water, electrolytes, vitamins, and bile salts.Intestinal villusIntestinal villusIntestinal villi (sing.: villus) are small, finger-like projections that extend into the lumen of the small intestine. Each villus is approximately 0.5–1.6 mm in length (in humans), and has many microvilli projecting from the enterocytes of its epithelium which collectively form the striated or brush border. Each of these microvilli are about 1 μm in length, around 1000 times shorter than a single villus.GlandGlandA gland is a cell or an organ in an animal's body that produces and secretes different substances that the organism needs, either into the bloodstream or into a body cavity or outer surface. A gland may also function to remove unwanted substances such as urine from the body. There are two types of gland, each with a different method of secretion.EpitheliumEpitheliumEpithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial (mesothelial) tissues line the outer surfaces of many internal organs, the corresponding inner surfaces of body cavities, and the inner surfaces of blood vessels. Epithelial tissue is one of the four basic types of animaltissue, along with connective tissue, muscle tissue and nervous tissue.Crypt (anatomy)Crypt (anatomy)Crypts are anatomical structures that are narrow but deep invaginations into a larger structure. One common type of anatomical crypt is the Crypts of Lieberkühn. However, it is not the only type: some types of tonsils also have crypts. Because these crypts allow external access to the deep portions of the tonsils, these tonsils are more vulnerable to infection.Johann Nathanael LieberkühnJohann Nathanael LieberkühnJohann Nathanael Lieberkühn (5 September 1711, in Berlin – 7 October 1756, in Berlin) was a German physician. His middle name is sometimes misspelled Nathaniel. Lieberkühn studied theology initially, and then moved to physics, in particular mechanics. It was only after this that he commenced medicine. In 1739 he moved to Leiden, in the Netherlands, and then a year later to London and Paris.Cell (biology)Cell (biology)Basic unit of life formsThe cell is the basic structural and functional unit of all forms of life or organisms. The term comes from the Latin word cellula meaning 'small room'. A biological cell basically consists of a semipermeablecell membrane enclosing cytoplasm that contains genetic material. Most cells are only visible under a microscope.HistologyHistologyHistology, also known as microscopic anatomy, microanatomy or histoanatomy, is the branch of biology that studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures visible without a microscope.

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