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Hyperpolarization (physics)

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Hyperpolarization is the spin polarization of the atomic nuclei of a material in a magnetic field far beyond thermal equilibrium conditions determined by the Boltzmann distribution. It can be applied to gases such as Xe and He, and small molecules where the polarization levels can be enhanced by a factor of 10–10 above thermal equilibrium levels. Hyperpolarized noble gases are typically used in magnetic resonance imaging (MRI) of the lungs.

Nuclear magnetic resonanceNuclear magnetic resonanceSpectroscopic technique based on change of nuclear spin stateBruker 700 MHz nuclear magnetic resonance (NMR) spectrometer.Nuclear Magnetic Resonance (NMR) basic principlesNuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are disturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus.Magnetic resonance imagingMagnetic resonance imagingMedical imaging techniqueMedical diagnostic method Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to form images of the organs in the body.Spin polarizationSpin polarizationIn particle physics, spin polarization is the degree to which the spin, i.e., the intrinsic angular momentum of elementary particles, is aligned with a given direction. This property may pertain to the spin, hence to the magnetic moment, of conduction electrons in ferromagnetic metals, such as iron, giving rise to spin-polarized currents. It may refer to (static) spin waves, preferential correlation of spin orientation with ordered lattices (semiconductors or insulators).Noble gasNoble gasGroup of low-reactive, gaseous chemical elementshalogens ← → alkali metalsThe noble gases (historically the inert gases, sometimes referred to as aerogens) are the members of group 18 of the periodic table: helium (He), neon (Ne), argon (Ar), krypton (Kr), xenon (Xe), radon (Rn) and, in some cases, oganesson (Og).Magnetic fieldMagnetic fieldIn magnetism and electromagnetism, magnetic field is a physical property of space that quantifies the magnetic influence at a given location.Helium-3Helium-3Helium-3 (He) is a light, stableisotope of helium with two protons and one neutron in a nucleus called helion. It is in contrast to the more common isotope, helium-4, which has two protons and two neutrons. Helium-3 and hydrogen-1 are the only stable nuclides with more protons than neutrons. It was discovered in 1939. Helium-3 atoms are fermionic and become a superfluid at the temperature of 2.491 mK.Isotopes of xenonIsotopes of xenonStandard atomic weightAr°(Xe)131.293±0.006131.29±0.01 (abridged)Naturally occurring xenon (54Xe) consists of nine isotopes: seven stableisotopes and two very long-lived radioactive isotopes: double electron capture has been observed in Xe (half-life 1.1 ± 0.2stat ± 0.1sys×10 years), and double beta decay in Xe (half-life 2.18 ×10 years), which are among the longest measured half-lives of all nuclides.Boltzmann distributionBoltzmann distributionIn statistical mechanics and mathematics, a Boltzmann distribution (also called Gibbs distribution) is a probability distribution or probability measure that gives the probability that a system will be in a certain state as a function of that state's energy and the temperature of the system.Spin quantum numberIn chemistry and quantum mechanics, the spin quantum number is a quantum number (designated s) that describes the intrinsic angular momentum (or spin angular momentum, or simply spin) of an electron or other particle. It has the same value for all particles of the same type, such as s = ⁠1/2⁠ for all electrons. It is an integer for all bosons, such as photons, and a half-odd-integer for all fermions, such as electrons and protons.In vivoIn vivoStudies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.Thermal equilibriumThermal equilibriumTwo physical systems are in thermal equilibrium if there is no net flow of thermal energy between them when they are connected by a path permeable to heat. Thermal equilibrium obeys the zeroth law of thermodynamics. A system is said to be in thermal equilibrium with itself if the temperature within the system is spatially uniform and temporally constant. Systems in thermodynamic equilibrium are always in thermal equilibrium, but the converse is not always true.

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