Lymphoid enhancer-binding factor 1More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 4: 108.05 – 108.17 MbChr 3: 130.9 – 131.02 MbPubMed searchWikidataLymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1gene. It is a member of T cell factor/lymphoid enhancer factor (TCF/LEF) family. FunctionLymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells.
HMG-boxIn molecular biology, the HMG-box (high-mobility group box) is a protein domain which is involved in DNA binding. The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.
HMGB1More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 13: 30.46 – 30.62 Mbn/aPubMed searchn/aWikidataHigh mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1gene. HMG-1 belongs to the high mobility group and contains a HMG-box domain. FunctionLike the histones, HMGB1 is among the most important chromatin proteins.
SOX2More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 3: 181.71 – 181.71 MbChr 3: 34.7 – 34.71 MbPubMed searchWikidataSRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.
SOX1More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 13: 112.07 – 112.07 MbChr 8: 12.45 – 12.45 MbPubMed searchWikidataSOX1 is a gene that encodes a transcription factor with a HMG-box (high mobility group) DNA-binding domain and functions primarily in neurogenesis. SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group), contain transcription factors related to SRY, the testis-determining factor.
TCF7L1Transcription factor 7-like 1, also known as TCF7L1, is a human gene. This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway.
TCF7More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 5: 134.11 – 134.15 MbChr 11: 52.25 – 52.28 MbPubMed searchWikidataTranscription factor 7 is the gene that in humans encodes for the TCF1 protein.
Sex-determining region Y proteinMore reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr Y: 2.79 – 2.79 MbChr Y: 2.66 – 2.66 MbPubMed searchWikidataSex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRYgene that is responsible for the initiation of male sex determination in therianmammals (placentals and marsupials).
ProteinBiomolecule consisting of chains of amino acid residuesA representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acidresidues.
DNA repairCellular mechanismDNA damage resulting in multiple broken chromosomesDiagram of DNA repair.In molecular biology, DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer.
Genetic recombinationGenetic recombination (also known as genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits that differ from those found in either parent. In eukaryotes, genetic recombination during meiosis can lead to a novel set of genetic information that can be further passed on from parents to offspring.
DNA replicationDNA replication is the process by which a cell makes exact copies of its DNA. This process occurs in all organisms and is essential to biological inheritance, cell division, and repair of damaged tissues. DNA replication ensures that each of the newly divided daughter cells receives its own copy of each DNA molecule. DNA most commonly occurs in double-stranded form, made up of two complementarystrands held together by base pairing of the nucleotides comprising each strand.
Transcription (biology)Transcription is the process of duplicating a segment of DNA into RNA for the purpose of gene expression. Some segments of DNA are transcribed into RNA molecules that can encode proteins, called messenger RNA (mRNA). Other segments of DNA are transcribed into RNA molecules called non-coding RNAs (ncRNAs). Both DNA and RNA are nucleic acids, composed of nucleotide sequences.*As an Amazon Associate I earn from qualifying purchases.