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Efflux pump

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An efflux pump is an active transporter in cells that moves out unwanted material. Efflux pumps are an important component in bacteria, particularly in their ability to remove antibiotics. The efflux process can also involve the movement of heavy metals, organic pollutants, plant-produced compounds, quorum sensing signals, bacterial metabolites, and neurotransmitters. All microorganisms, with a few exceptions, have highly conserved DNA sequences in their genome that encode efflux pumps.

Active transportActive transportIn cellular biology, active transport is the movement of molecules or ions across a cell membrane from a region of lower concentration to a region of higher concentration—against the concentration gradient. Active transport requires cellular energy to achieve this movement. There are two types of active transport: primary active transport that uses adenosine triphosphate (ATP), and secondary active transport that uses an electrochemical gradient.UniporterUniporterClass of membrane transport proteins Comparison of transport proteins Uniporters, also known as solute carriers or facilitated transporters, are a type of membrane transport protein that passively transports solutes (small molecules, ions, or other substances) across a cell membrane. It uses facilitated diffusion for the movement of solutes down their concentration gradient from an area of high concentration to an area of low concentration.AntiporterAntiporterAn antiporter (also called exchanger or counter-transporter) is an integral membrane protein that uses secondary active transport to move two or more molecules in opposite directions across a phospholipid membrane. It is a type of cotransporter, which means that uses the energetically favorable movement of one molecule down its electrochemical gradient to power the energetically unfavorable movement of another molecule up its electrochemical gradient.ProteinProteinBiomolecule consisting of chains of amino acid residuesA representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acidresidues.SymporterSymporterA symporter is an integral membrane protein that is involved in the transport of two (or more) different molecules across the cell membrane in the same direction. The symporter works in the plasma membrane and molecules are transported across the cell membrane at the same time, and is, therefore, a type of cotransporter. The transporter is called a symporter, because the molecules will travel in the same direction in relation to each other.Xenobiotic metabolismXenobiotic metabolismXenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as drugs and poisons. These pathways are a form of biotransformation present in all major groups of organisms, and are considered to be of ancient origin.BacteriaBacteriaDomain of microorganismsSynonyms"Bacteria" (Cohn 1872) Cavalier-Smith 1983"Bacteria" Haeckel 1894"Bacteria" Cavalier-Smith 2002"Bacteriaceae" Cohn 1872a"Bacteriobionta" Möhn 1984"Bacteriophyta" Schussnig 1925"Eubacteria" Woese and Fox 1977"Neobacteria" Möhn 1984"Schizomycetaceae" de Toni and Trevisan 1889"Schizomycetes" Nägeli 1857Bacteria are ubiquitous, mostly free-living organisms often consisting of one biological cell.NeurotransmitterNeurotransmitterA neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotransmitters are released from synaptic vesicles into the synaptic cleft where they are able to interact with neurotransmitter receptors on the target cell. Some neurotransmitters are also stored in large dense core vesicles.Adenosine triphosphateAdenosine triphosphateAdenosine triphosphate (ATP) is a nucleoside triphosphate that provides free energy of approximately 58 kJ/mol (0.6 eV) to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis. Found in all known forms of life, it is often referred to as the "molecular unit of currency" for intracellular energy transfer.Electrochemical potentialIn electrochemistry, the electrochemical potential (ECP), μ, is a thermodynamic measure of chemical potential that does not omit the energy contribution of electrostatics. Electrochemical potential is expressed in the unit of J/mol.HydrogenHydrogenChemical element with atomic number 1 (H)–↑H↓Li(none) ← hydrogen → heliumCell membraneCell membraneThe cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a semipermeablebiological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).

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