ThiazideThiazides () are a class of diuretics based on the chemical structure of benzothiadiazine. Thiazides are used in the treatment of hypertension. The first approved drug of this class was chlorothiazide in 1958. Thiazide-like diuretics, such as indapamide, are sometimes called thiazides because they act on the same receptor, but do not have the thiazide chemical structure.DiuresisDiuresis () is the excretion of urine, especially when excessive (polyuria). The term collectively denotes the physiologic processes underpinning increased urine production by the kidneys during maintenance of fluid balance. In healthy people, the drinking of extra water produces mild diuresis to maintain the body water balance.
AcetazolamideAcetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, acute mountain sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), and heart failure, and to alkalinize urine. It may be used long term for the treatment of open angle glaucoma and short term for acute angle closure glaucoma until surgery can be carried out. It is taken by mouth or injection into a vein.
VasopressinMammalian hormone released from the pituitary glandPharmaceutical compoundMore reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 20: 3.08 – 3.08 MbChr 2: 130.42 – 130.42 MbPubMed searchWikidataMammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptideprohormone in neurons in the hypothalamus, and is converted to AVP.
AldosteroneAldosterone is the main mineralocorticoidsteroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na), and potassium (K) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron.
HypertensionLong-term high blood pressure in the arteriesMedical conditionHypertension, also known as high blood pressure, is a long-termmedical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms itself. It is, however, a major risk factor for stroke, coronary artery disease, heart failure, atrial fibrillation, peripheral arterial disease, vision loss, chronic kidney disease, and dementia.
KidneyIn humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and right in the retroperitoneal space, and in adult humans are about 12 centimetres (4+1⁄2 inches) in length. They receive blood from the paired renal arteries; blood exits into the paired renal veins.
UrineUrine is the fluid excreted by the kidneys of vertebrates to clear the bloodstream of excess water and metabolic by-products including urea, uric acid, and creatinine. In mammals, urine travels from the kidneys via the ureters to the bladder for storage until urination. Placental mammals expel urine from the bladder through the urethra, whereas other vertebrates urinate through the cloaca. Urine plays an important role in the earth's nitrogen cycle.
WaterNames Preferred IUPAC nameWaterSystematic IUPAC nameOxidane (not in common use)Other names Hydrogen oxideHydrogen hydroxide (H2O or HOH)Hydroxylic acidDihydrogen monoxide (DHMO) (parody name)Dihydrogen oxideHydric acidHydrohydroxic acidHydroxic acidHydroxoic acidHydrolμ-Oxidodihydrogenκ-Hydroxylhydrogen(0)AquaNeutral liquidOxygen dihydride (may be considered incorrect)Identifiers CAS Number7732-18-53D model (JSmol)Interactive imageBeilstein Reference3587155 ChEBICHEBI:15377ChEMBLChEMBL1098659ChemSpider937DrugBankDB09145ECHA InfoCard100.028.902EC Number231-791-2Gmelin Reference117 KEGGC00001PubChemCID962RTECS numberZC0110000UNII059QF0KO0RCompTox Dashboard(EPA)DTXSID6026296InChIInChI=1S/H2O/h1H2Key: XLYOFNOQVPJJNP-UHFFFAOYSA-NSMILESOProperties Chemical formulaH2OMolar mass18.015 g·mol Appearance Almost colorless or white crystalline solid, almost colorless liquid, with a hint of blue, colorless gas OdorOdorless DensityLiquid (1 atm, VSMOW):0.99984283(84) g/mL at 0 °C0.99997495(84) g/mL at 3.983035(670) °C (temperature of maximum density, often 4 °C)0.99704702(83) g/mL at 25 °C0.96188791(96) g/mL at 95 °CSolid:0.9167 g/mL at 0 °CMelting point0.00 °C (32.00 °F; 273.15 K) Boiling point99.98 °C (211.96 °F; 373.13 K) SolubilityPoorly soluble in haloalkanes, aliphatic and aromatic hydrocarbons, ethers.AntidiureticAn antidiuretic is a substance that helps to control fluid balance in an animal's body by reducing urination, opposing diuresis. Its effects are opposite that of a diuretic. The major endogenous antidiuretics are antidiuretic hormone (ADH; also called vasopressin) and oxytocin. Antidiuretic hormones are present in high concentrations under conditions of dehydration as a pathophysiological mechanism to promote water reabsorption.
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