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Citric acid cycle

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Interconnected biochemical reactions releasing energyOverview of the citric acid cycleThe citric acid cycle—also known as the Krebs cycle, Szent–Györgyi–Krebs cycle, or TCA cycle (tricarboxylic acid cycle)—is a series of biochemical reactions that release the energy stored in nutrients through acetyl-CoAoxidation. The energy released is available in the form of ATP.

Cellular respirationCellular respirationCellular respiration is the process of oxidizing biological fuels using an inorganic electron acceptor, such as oxygen, to drive production of adenosine triphosphate (ATP), which stores chemical energy in a biologically accessible form.Anaerobic respirationAnaerobic respirationAnaerobic respiration is respiration using electron acceptors other than molecular oxygen (O2) in its electron transport chain. In aerobic organisms, electrons are shuttled to an electron transport chain, and the final electron acceptor is oxygen. Molecular oxygen is an excellent electron acceptor. Anaerobes instead use less-oxidizing (in either thermodynamic or kinetics sense) substances such as nitrate (NO3), fumarate (C4H2O4), sulfate (SO4), or elemental sulfur (S).Acetyl-CoAAcetyl-CoAAcetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism. Its main function is to deliver the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production. Coenzyme A (CoASH or CoA) consists of a β-mercaptoethylamine group linked to pantothenic acid (vitamin B5) through an amide linkage and 3', 5'-phosphorylated ADP.RedoxRedoxRedox ( , , reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change. Oxidation is the loss of electrons or an increase in the oxidation state. Reduction is the gain of electrons or a decrease in the oxidation state. The oxidation and reduction processes occur simultaneously in the chemical reaction. Redox reactions fall into two classes.Adenosine triphosphateAdenosine triphosphateNames IUPAC nameAdenosine 5′-(tetrahydrogen triphosphate)Systematic IUPAC nameO-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphateIdentifiers CAS Number56-65-5 (free acid)34369-07-8 (disodium salt hydrate)3D model (JSmol)Interactive imageInteractive imageChEBICHEBI:15422ChEMBLChEMBL14249ChemSpider5742DrugBankDB00171ECHA InfoCard100.000.258IUPHAR/BPS1713KEGGC00002PubChemCID5957UNII8L70Q75FXECompTox Dashboard(EPA)DTXSID6022559InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1Key: ZKHQWZAMYRWXGA-KQYNXXCUSA-NKey: ZKHQWZAMYRWXGA-KQYNXXCUBGSMILESO=P(O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3Oc1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)NProperties Chemical formulaC10H16N5O13P3Molar mass507.18 g/mol Density1.04 g/cm (disodium salt) Melting point187 °C (369 °F; 460 K) disodium salt; decomposes Acidity (pKa) 0.9, 1.4, 3.8, 6.5 UV-vis (λmax) 259 nm Absorbanceε259 = 15.4 mM cm Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).Yverify ( ?)Chemical reactionChemical reactionProcess that leads to chemical changesA thermite reaction using iron(III) oxide. The sparks flying outwards are globules of molten iron trailing smoke in their wake.A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an energy change as new products are generated.Amino acidAmino acidOrganic compounds containing amine and carboxylic groupsStructure of a typical L-alpha-amino acid in the "neutral" formAmino acids are organic compounds that contain both amino and carboxylic acidfunctional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 appear in the genetic code of life.NutrientNutrientA nutrient is a substance used by an organism to survive, grow and reproduce. The requirement for dietary nutrient intake applies to animals, plants, fungi and protists. Nutrients can be incorporated into cells for metabolic purposes or excreted by cells to create non-cellular structures such as hair, scales, feathers, or exoskeletons.FermentationFermentationFermentation is a type of anaerobic metabolism that harnesses the redox potential of the reactants to make adenosine triphosphate (ATP) and organic end products. Organic molecules, such as glucose or other sugars, are catabolized and their electrons are transferred to other organic molecules (cofactors, coenzymes, etc.).Precursor (chemistry)Precursor (chemistry)In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound. In biochemistry, the term "precursor" often refers more specifically to a chemical compound preceding another in a metabolic pathway, such as a protein precursor.OrganismOrganismAn organism is any living thing that functions as an individual. Such a definition raises more problems than it solves, not least because the concept of an individual is also difficult. Several criteria, few of which are widely accepted, have been proposed to define what constitutes an organism. Among the most common is that an organism has autonomous reproduction, growth, and metabolism. This would exclude viruses, even though they evolve like organisms.

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