FK1012FK1012 is a dimer consisting of two molecules of tacrolimus (FK506) linked via their vinyl groups. It is used as a research tool in chemically induced dimerization applications. FK1012 is a chemical inducer of dimerization (CID) which makes the protein capable of dimerization or oligomerization of fusion proteins containing one or more FKBP12 domains. It is used in pharmacology to act as a mediator in the formation of FK506 dimer.
FKBPThe FKBPs, or FK506 binding proteins, constitute a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. FKBPs have been identified in many eukaryotes, ranging from yeast to humans, and function as protein foldingchaperones for proteins containing proline residues. Along with cyclophilin, FKBPs belong to the immunophilin family.
Signal transductionSignal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway.
Fusion proteinFusion proteins or chimeric proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins. Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins. Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics.DNA constructA DNA construct is an artificially-designed segment of DNA borne on a vector that can be used to incorporate genetic material into a target tissue or cell. A DNA construct contains a DNA insert, called a transgene, delivered via a transformation vector which allows the insert sequence to be replicated and/or expressed in the target cell. This gene can be cloned from a naturally occurring gene, or synthetically constructed.
In vivoStudies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
TacrolimusTacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After an allogenicorgan transplant, the risk of organ rejection is moderate; tacrolimus is used to lower the risk of organ rejection. Tacrolimus is also sold as a topical medication for treating T cell-mediated diseases, such as eczema and psoriasis.
OR gateThe OR gate is a digital logic gate that implements logical disjunction. The OR gate outputs "true" if any of its inputs is "true"; otherwise it outputs "false". The input and output states are normally represented by different voltage levels. DescriptionAny OR gate can be constructed with two or more inputs. It outputs a 1 if any of these inputs are 1, or outputs a 0 only if all inputs are 0.AND gateThe AND gate is a basic digital logic gate that implements the logical conjunction (∧) from mathematical logic – AND gates behave according to their truth table. A HIGH output (1) results only if all the inputs to the AND gate are HIGH (1). If any of the inputs to the AND gate are not HIGH, a LOW (0) is outputted. The function can be extended to any number of inputs by multiple gates up in a chain.Biological computingBiological computers use biologically derived molecules — such as DNA and/or proteins — to perform digital or real computations. The development of biocomputers has been made possible by the expanding new science of nanobiotechnology.*As an Amazon Associate I earn from qualifying purchases.