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Beta oxidation

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In biochemistry and metabolism, beta oxidation (also β-oxidation) is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA. The acetyl-CoA product of this step of fatty acid metabolism enters the citric acid cycle, generating NADH and FADH2, which are electron carriers used in the electron transport chain.

Electron transport chainElectron transport chainAn electron transport chain (ETC) is a series of protein complexes and other molecules which transferelectrons from electron donors to electron acceptors via redox reactions (both reduction and oxidation occurring simultaneously) and couples this electron transfer with the transfer of protons (H ions) across a membrane. Many of the enzymes in the electron transport chain are embedded within the membrane.Citric acid cycleCitric acid cycleThe citric acid cycle—also known as the Krebs cycle, Szent–Györgyi–Krebs cycle, or TCA cycle (tricarboxylic acid cycle)—is a series of biochemical reactions that release the energy stored in nutrients through acetyl-CoAoxidation. The energy released is available in the form of ATP. The Krebs cycle is used by organisms that generate energy via respiration, either anaerobically or aerobically (organisms that ferment use different pathways).Fatty acidFatty acidIn chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, from 4 to 28.MetabolismMetabolismSet of chemical reactions in organismsSimplified view of cellular metabolismMetabolism (, from Greek μεταβολή (metabolē) 'change') refers to the set of life-sustaining chemical reactions that occur within living organisms.Acetyl-CoAAcetyl-CoAThis article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages) This article has an unclear citation style. The reason given is: Multiple page-numbers in a single ref that is used multiple times: unclear which supports which. Some ISBN might be for wrong edition of the book. Need page-numbers for refs to whole broad-coverage textbooks.MitochondriaMitochondriaOrganelle in eukaryotic cells responsible for respirationA mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects.CytosolCytosolThe cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells (intracellular fluid (ICF)). It is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into many compartments.Fatty acid metabolismFatty acid metabolism consists of various metabolic processes involving or closely related to fatty acids, a family of molecules classified within the lipid macronutrient category. These processes can mainly be divided into (1) catabolic processes that generate energy and (2) anabolic processes where they serve as building blocks for other compounds. In catabolism, fatty acids are metabolized to produce energy, mainly in the form of adenosine triphosphate (ATP).CatabolismCatabolismCatabolism () is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions. Catabolism breaks down large molecules (such as polysaccharides, lipids, nucleic acids, and proteins) into smaller units (such as monosaccharides, fatty acids, nucleotides, and amino acids, respectively). Catabolism is the breaking-down aspect of metabolism, whereas anabolism is the building-up aspect.BiochemistryBiochemistryStudy of chemical processes of living organismsBiochemistry, or biological chemistry (distinct from chemical biology), is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines.Flavin adenine dinucleotideFlavin adenine dinucleotideIn biochemistry, flavin adenine dinucleotide (FAD) is a redox-active coenzyme associated with various proteins, which is involved with several enzymatic reactions in metabolism. A flavoprotein is a protein that contains a flavin group, which may be in the form of FAD or flavin mononucleotide (FMN). Many flavoproteins are known: components of the succinate dehydrogenase complex, α-ketoglutarate dehydrogenase, and a component of the pyruvate dehydrogenase complex.Nicotinamide adenine dinucleotideNicotinamide adenine dinucleotideCoenzymeChemical compoundNicotinamide adenine dinucleotide (NAD+) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adeninenucleobase and the other, nicotinamide. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD and NADH (H for hydrogen), respectively.ProkaryoteProkaryoteA prokaryote (; from Ancient Greekpró, meaning 'before'; and káruon, meaning 'nut' or 'kernel'), less commonly spelled procaryote, is a cellularorganism that lacks a distinct cell nucleus or other membrane-bound organelles. In the earlier two-empire system, prokaryotes formed the empireProkaryota; in the current three-domain system, based upon molecular phylogenetics, prokaryotes are divided into two domainsBacteria and Archaea.

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