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Autoimmunity

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In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an "autoimmune disease".

Autoimmune diseaseAutoimmune diseaseDisorders of adaptive immune systemMedical conditionAn autoimmune disease is a condition causing disease that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated that there are more than 80 recognized autoimmune diseases, with recent scientific evidence suggesting the existence of potentially more than 100 distinct conditions.Immune responseImmune responseAn immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.Hashimoto's thyroiditisHashimoto's thyroiditisAutoimmune diseaseMedical conditionHashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on, symptoms may not be noticed. Over time, the thyroid may enlarge, forming a painless goiter. Most people eventually develop hypothyroidism with accompanying weight gain, fatigue, constipation, hair loss, and general pain. After many years, the thyroid typically shrinks in size.LupusLupusAutoimmune disease in which the immune system attacks healthy tissueMedical conditionLupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe.ImmunologyImmunologyImmunology is a branch of biology and medicine that covers the study of immune systems in all organisms.Eosinophilic granulomatosis with polyangiitisEosinophilic granulomatosis with polyangiitisEosinophilic granulomatosis with polyangiitis (EGPA), formerly known as allergic granulomatosis, is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy). It usually manifests in three stages. The early (prodromal) stage is marked by airway inflammation; almost all patients experience asthma or allergic rhinitis. The second stage is characteriz…Coeliac diseaseCoeliac diseaseAutoimmune disorderMedical conditionCoeliac disease (Commonwealth English) or celiac disease (American English) is a chronic autoimmune disease, mainly affecting the small intestine. It is caused by an abnormal immune system response to gluten, a protein found in wheat and other grains such as barley and rye. Coeliac disease causes a wide range of symptoms and complications that can affect multiple organs outside the gastrointestinal tract.Tissue (biology)Tissue (biology)In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function. Tissues occupy a biological organizational level between cells and a complete organ. Accordingly, organs are formed by the functional grouping of multiple tissues. The English word "tissue" derives from the French word "tissu", meaning "fabric", derived from the verb “tisser”, "to weave".Cell biologyCell biologyCell biology, cellular biology, or cytology, is the branch of biology that studies the structure, function, and behavior of the cells. All organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of an organism. Cell biology encompasses both prokaryotic and eukaryotic cells, with subtopics including the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition.Type 1 diabetesType 1 diabetesForm of diabetes mellitusMedical conditionType 1 diabetes (T1D), or type 1 diabetes mellitus, is an autoimmune disease that occurs when the body's immune system destroys beta cells in the pancreas that produce the hormone insulin. Insulin is used by the body to store and convert blood sugar into energy. T1D results in high blood sugar levels in the body prior to treatment due to the lack of insulin.Sjögren's diseaseSjögren's diseaseAutoimmune diseaseMedical conditionSjögren's disease (SjD), previously known as Sjögren syndrome or Sjögren's syndrome (SjS, SS), is a long-termautoimmune disease that primarily affects the body's exocrine glands, particularly the lacrimal and salivary glands. Common symptoms include dry mouth and dry eyes, and in a subset of patients can seriously affect other organ systems, such as the lungs, kidneys, and nervous system.Henoch–Schönlein purpuraHenoch–Schönlein purpuraIgA vasculitis, previously known as Henoch–Schönlein purpura (HSP), is an autoimmune disease that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain (arthralgia) and abdominal pain.

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