UK-414,495 is a drug developed by
Pfizer
Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...
for the treatment of
female sexual arousal disorder. UK-414,495 acts as a potent, selective inhibitor of the enzyme
neutral endopeptidase
Neprilysin (; also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10) and common acute lymphoblastic leukemia antigen (CALLA)) is an enzyme that in humans is encoded by the ''MME'' ge ...
, which normally serves to break down the
neuropeptide
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...
VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation.
See also
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ABT-670
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ABT-724
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Bremelanotide
Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, ...
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Cabergoline
Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications. It is taken by mouth.
Cabergoline is an ...
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Flibanserin
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Testosterone (patch) The testosterone patch, brand name Intrinsa among others, was designed to treat female sexual dysfunction.
Mechanism of action
Testosterone patches works by releasing the hormone testosterone through the skin into the bloodstream. In women, testos ...
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Melanotan II
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Pramipexole
Pramipexole, sold under the brand Mirapex among others, is a medication used to treat Parkinson's disease and restless legs syndrome. In Parkinson's disease it may be used alone or together with levodopa. It is taken by mouth. Pramipexole is a ...
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PF-219,061
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S-17092
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Tibolone
References
Hydrolase inhibitors
Female sexual dysfunction drugs
Thiadiazoles
Carboxamides
Carboxylic acids
Aphrodisiacs
Cyclopentanes
Drugs developed by Pfizer
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