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Troponin T (shortened TnT or TropT) is a part of the troponin complex, which are
Troponin T (shortened TnT or TropT) is a part of the troponin complex, which are protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
s integral to the contraction of skeletal and heart muscles. They are expressed in skeletal and cardiac myocyte
A muscle cell, also known as a myocyte, is a mature contractile Cell (biology), cell in the muscle of an animal. In humans and other vertebrates there are three types: skeletal muscle, skeletal, smooth muscle, smooth, and Cardiac muscle, cardiac ...
s. Troponin T binds to tropomyosin and helps position it on actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ...
, and together with the rest of the troponin complex, modulates contraction of striated muscle. The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs. It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay
An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity ...
.
Subtypes
* Slow skeletal troponin T1, TNNT1 (19q13.4, ) * Cardiac troponin T2, TNNT2 (1q32, ) * Fast skeletal troponin T3, TNNT3 (11p15.5, )Reference values
The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL. The reference range for the high sensitivity troponin T is a normal < 14 ng/L, borderline of 14-52 ng/L, and elevated of >52 ng/L.Background
The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. Increased troponin T levels after an episode of chest pain indicates myocardial infarction. It was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He also developed the troponin T assay. In patients with non-severe asymptomatic aortic valve stenosis and no overtcoronary artery disease
Coronary artery disease (CAD), also called coronary heart disease (CHD), or ischemic heart disease (IHD), is a type of cardiovascular disease, heart disease involving Ischemia, the reduction of blood flow to the cardiac muscle due to a build-up ...
, the increased troponin T (above 14 pg/mL) was found associated with an increased 5-year event rate of ischemic cardiac events ( myocardial infarction, percutaneous coronary intervention, or coronary artery bypass surgery). In patients with stable coronary artery disease
Coronary artery disease (CAD), also called coronary heart disease (CHD), or ischemic heart disease (IHD), is a type of cardiovascular disease, heart disease involving Ischemia, the reduction of blood flow to the cardiac muscle due to a build-up ...
, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack).
See also
* Troponin C * Troponin I * Calcium-binding protein *Sliding filament model
Sliding may refer to:
* Sliding (dance), also floating or gliding, a group of footwork-oriented dance techniques
* Slide (baseball), an attempt by a baseball runner to avoid getting tagged out
* Sliding (motion)
See also
* Slide (disambiguation)
...
References
External links
* {{Cytoskeletal Proteins Troponin