Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

that in humans is encoded by the ''TRPC5''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. TrpC5 is subtype of the TRPC family of mammalian

transient receptor potential Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), T ...

ion channel Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ...

Function

TrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with

TRPC1 Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the ''TRPC1'' gene. Function TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. It is a nonspecific cation ...

, TRPC3, and TRPC4. It also interacts with multiple proteins including

calmodulin Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the bi ...

CABP1 Calcium binding protein 1 is a protein that in humans is encoded by the CABP1 gene. Calcium-binding protein 1 is a calcium-binding protein discovered in 1999. It has two EF hand motifs and is expressed in neuronal cells in such areas as hipp ...

, enkurin, Na⁺–H⁺ exchange regulatory factor ( NHERF), interferon-induced GTP-binding protein ( MX1), ring finger protein 24 (

RNF24 Ring finger protein 24 is a protein that in humans is encoded by the ''RNF24'' gene. RNF24 binds TRPC6 (603652) and other transient receptor potential cation channel ( TRPC) family members and is involved in regulation of intracellular traff ...

), and SEC14 domain and spectrin repeat-containing protein 1 ( SESTD1). TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity and neurological behavior. It was established in 2021 that TRPC5 is a component of the dental cold sensing system.

Activation

Homomultimeric TRPC5 and heteromultimeric TRPC5-

channels are activated by extracellular reduced

thioredoxin Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by ''TXN'' and '' TXN2'' genes. Loss-of-fu ...

. This channel has also been found to be involved in the action of anaesthetics such as

chloroform Chloroform, or trichloromethane, is an organic compound with formula C H Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various re ...

halothane Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain anaesthesia. One of its benefits is that it does not increase the production of saliva, which can be particularly useful i ...

and

propofol Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation ...

Interactions

TRPC5 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizat ...

with STMN3,

, and TRPC4.

References

External links

* Ion channels {{membrane-protein-stub

Function

Activation

Interactions

See also

References

Further reading

External links