Sulfotransferases (SULTs) are

transferase A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds of ...

enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine. The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R-OSO₃⁻), whereas an amine leads to a sulfamate (R-NH-SO₃⁻). Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.

Examples

The following are examples of sulfotransferases: *

carbohydrate sulfotransferase Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular com ...

CHST1 Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the ''CHST1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generatio ...

, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9,

CHST10 Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the ''CHST10'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generat ...

CHST11 Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the ''CHST11'' gene. Clinical relevance Mutations in this gene have been associated to susceptibility for osteoarthritis. Model organisms Model organisms have been used ...

, CHST12, CHST13, CHST14 * galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4 * heparan sulfate 2-O-sulfotransferase: HS2ST1 *

heparan sulfate 3-O-sulfotransferase Glucosaminyl 3-O-sulfotransferase may refer to: * (heparan sulfate)-glucosamine 3-sulfotransferase 1, an enzyme * (heparan sulfate)-glucosamine 3-sulfotransferase 2, an enzyme * (heparan sulfate)-glucosamine 3-sulfotransferase 3, an enzyme ...

HS3ST1 Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the ''HS3ST1'' gene. Function Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structur ...

, HS3ST2,

HS3ST3A1 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the ''HS3ST3A1'' gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carr ...

HS3ST3B1 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the ''HS3ST3B1'' gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry ...

, HS3ST4, HS3ST5, HS3ST6 * heparan sulfate 6-O-sulfotransferase: HS6ST1, HS6ST2, HS6ST3 * N-deacetylase/N-sulfotransferase: NDST1, NDST2,

NDST3 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the ''NDST3'' gene. It catalyses the reaction:3'-phosphoadenylyl sulfate + α-D-glucosaminyl- heparan_sulfate">nowiki/>heparan_sulfate.html" ...

, NDST4 *

tyrosylprotein sulfotransferase Tyrosylprotein sulfotransferase is an enzyme that catalyzes tyrosine sulfation. Function Tyrosylprotein sulfotransferase is the enzyme that catalyzes the sulfation reaction of protein tyrosines, a post-translational modification of protein ...

: TPST1, TPST2 * uronyl-2-sulfotransferase *

Estrone sulfotransferase Estrone sulfotransferase (EST) (), also known as estrogen sulfotransferase, is an enzyme that catalyzes the transformation of an unconjugated estrogen like estrone into a sulfated estrogen like estrone sulfate. It is a steroid sulfotransferase ...

* Chondroitin 4-sulfotransferase * other: SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1,

SULT1C2 Sulfotransferase 1C2 is an enzyme that in humans is encoded by the ''SULT1C2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ' ...

SULT1C3 Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the ''SULT1C3'' gene. Function Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. ...

, SULT1C4, SULT1D1P,

SULT1E1 Estrogen sulfotransferase is an enzyme that in humans is encoded by the ''SULT1E1'' gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are ...

SULT2A1 Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the ''SULT2A1'' gene. Function Sulfotransferase enzymes catalyze the sulfate conjugation ...

, SULT2B1, SULT4A1, SULT6B1

References

External links

* * {{Biochemistry-stub

Examples

See also

References

External links