Sinus tubercle (also known as sinual tubercle or Müllerian eminence) is the proliferation of

endoderm Endoderm is the innermost of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer). Cells migrating inward along the archenteron form the inner layer of the gast ...

induced by the

paramesonephric ducts Paramesonephric ducts (or Müllerian ducts) are paired ducts of the embryo that run down the lateral sides of the genital ridge and terminate at the sinus tubercle in the primitive urogenital sinus. In the female, they will develop to form the fal ...

. It is located in the developing fetus between the orifices of the

mesonephric ducts The mesonephric duct (also known as the Wolffian duct, archinephric duct, Leydig's duct or nephric duct) is a paired organ that forms during the embryonic development of humans and other mammals and gives rise to male reproductive organs. Stru ...

on the

urogenital sinus The urogenital sinus is a part of the human body only present in the development of the urinary and reproductive organs. It is the ventral part of the cloaca, formed after the cloaca separates from the anal canal during the fourth to seventh we ...

. The uterovaginal primoridium, which is a fusion of the caudal ends of

, contacts the dorsal wall of the

and, induces the formation of the sinus tubercle. This occurs in both sexes: *In the female the

mesonephric duct The mesonephric duct (also known as the Wolffian duct, archinephric duct, Leydig's duct or nephric duct) is a paired Organ (anatomy), organ that forms during the embryonic development of humans and other mammals and gives rise to male Sex organ, r ...

loses all association with the gonad and, disappears. The sinus tubercle then gives rise to the

sino-vaginal bulb The sinovaginal bulb is a transitional structure in the development of female genitalia, and is one of a pair of endodermal outgrowths of the urogenital sinus, which later fuse to form the lower part of the vagina. The lower third of the vagina is d ...

s and, when it later becomes solid it is referred to as the

vaginal plate In mammals, the vagina is the elastic, muscular part of the female genital tract. In humans, it extends from the vestibule to the cervix. The outer vaginal opening is normally partly covered by a thin layer of mucosal tissue called the hym ...

. It likewise gives rise to the

hymen The hymen is a thin piece of mucosal tissue that surrounds or partially covers the external vaginal opening. It forms part of the vulva, or external genitalia, and is similar in structure to the vagina. In children, a common appearance of the h ...

, which eventually breaks down in most cases. * In the males, the sinus tubercle gives rise to the

seminal colliculus The seminal colliculus (Latin ''colliculus seminalis''), or verumontanum, of the prostatic urethra is a landmark distal to the entrance of the ejaculatory ducts (on both sides, corresponding vas deferens and seminal vesicle feed into corresponding ...

References

* *Moore Persaud, ''Medical embryology'' 2003 {{Development of urinary and reproductive systems Animal developmental biology Embryology