In
organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clay ...
sulfamation is the installation of either of two related
functional group
In organic chemistry, a functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions. The same functional group will undergo the same or similar chemical reactions regardless of the res ...
s, sulfamic acid (R
2NSO
3H) and sulfamate (R
2NSO
3−). Typical methods entail reaction of primary amines with sources of sulfur trioxide such as
pyridine-sulfur trioxide:
[{{cite journal , doi=10.1021/jo01314a033, title=Sulfonylamine-Mediated Sulfamation of Amines. A Mild, High Yield Synthesis of Sulfamic Acid Salts, year=1980, last1=DuBois, first1=Grant E., last2=Stephenson, first2=Rebecca A., journal=The Journal of Organic Chemistry, volume=45, issue=26, pages=5371–5373]
:RNH
2 + SO
3 → RNHSO
3H
Sulfamation can also be effected by treating the amine with the sulfate ester of
catechol (C
6H
4O
2SO
2).
References
Sulfur oxoacids
Sulfamates