Sofronio may refer to:
*
Sofronio Española, a 2nd class municipality in Palawan, Philippines
*
Sofronio Palahang (born 1967), Filipino tennis player
*
Sofronio Roxas (1938–1984), Filipino farmer and dissident against the Marcos dictatorship
*
Sofronio Vasquez (born 1992), winner of
''The Voice'' season 26
{{disambiguation, given name