In
molecular biology, U24 is a member of the
C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs.
C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets.
U24 is encoded within an intron of the gene for
ribosomal protein L7a in mammals, chicken and Fugu.
The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene.
snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.
An experiment that looked at 22 different non-small-cell
lung cancer tissues found that
SNORD33,
SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.
References
External links
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Small nuclear RNA
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