Afadin- and alpha-actinin-binding protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''SSX2IP''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation.
The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.
Interactions
SSX2IP has been initially described as a protein to
interact with
MLLT4 and
Actinin, alpha 1.
[ In the context of centrosome maturation and ciliogenesis it has been shown to interact with WDR8.]
References
Further reading
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