Stage-specific embryonic antigen 3 (SSEA-3) is a glycosphingolipid, specifically, an

oligosaccharide An oligosaccharide (; ) is a carbohydrate, saccharide polymer containing a small number (typically three to ten) of monosaccharides (simple sugars). Oligosaccharides can have many functions including Cell–cell recognition, cell recognition and ce ...

composed of five

carbohydrate A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' ...

units connected to a

sphingolipid Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sp ...

, also known as globoside-5 (Gb5). Sphingolipids were originally discovered in 1884 by Johann Ludwig Wilhelm Thudichum who named them after the

Sphinx A sphinx ( ; , ; or sphinges ) is a mythical creature with the head of a human, the body of a lion, and the wings of an eagle. In Culture of Greece, Greek tradition, the sphinx is a treacherous and merciless being with the head of a woman, th ...

Greek mythology Greek mythology is the body of myths originally told by the Ancient Greece, ancient Greeks, and a genre of ancient Greek folklore, today absorbed alongside Roman mythology into the broader designation of classical mythology. These stories conc ...

in reference to the unresolved riddle of their function. It is now known that sphingolipids function as key players in cell signaling and the SSEA-3 molecule as a whole plays a key role in identifying many types of

mammal A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three ...

ian cells with

pluripotent Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the greater its potency. Potency is also described as the gene activation potential within a cell, which like a continuum ...

and

stem cell In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell ...

-like characteristics.

References

{{Sphingolipids Glycolipids