''Rubulavirinae'' is a subfamily of
virus
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea.
Since Dmitri Ivanovsky's 1 ...
es in the family ''
Paramyxoviridae
''Paramyxoviridae'' (from Ancient Greek, Greek ''para-'' “by the side of” and ''myxa'' “mucus”) is a family of negative-strand RNA viruses in the order ''Mononegavirales''. Vertebrates serve as natural hosts. Diseases associated with this ...
''.
Humans, apes, pigs, and dogs serve as natural hosts. There are currently 18 species in the two genera ''Orthorubulavirus'' and ''Pararubulavirus''.
Diseases associated with this genus include
mumps
MUMPS ("Massachusetts General Hospital Utility Multi-Programming System"), or M, is an imperative, high-level programming language with an integrated transaction processing key–value database. It was originally developed at Massachusetts Gener ...
.
Members of the subfamily are collectively called rubulaviruses. The subfamily was previously a genus named ''Rubulavirus'' but was elevated to subfamily in 2018.
Viruses of this subfamily appear to be most closely related to members of ''
Avulavirinae
''Avulavirinae'' is a subfamily of viruses in the family ''Paramyxoviridae''. Members of the subfamily are collectively known as avulaviruses. All members of the subfamily primarily infect birds. ''Avulavirinae'' was previously recognized as the g ...
''.
Taxonomy
Subfamily: ''Rubulavirinae''
:Genus: ''
Orthorubulavirus''
:Genus: ''
Pararubulavirus''
Structure
Rubulavirions are enveloped, with spherical geometries. The diameter is around 150 nm. Rubulavirus genomes are linear, around 15kb in length. The genome codes for 8 proteins.
[
]
Life cycle
Viral replication is cytoplasmic. Entry into the host cells is achieved after viral attachment to host cells. Replication follows the negative stranded RNA virus replication model. Negative-stranded RNA virus transcription, using polymerase stuttering, through co-transcriptional RNA editing is the method of transcription. The virus exits the host cell by budding. Humans, apes, pigs, and dogs serve as the natural host. Transmission routes are respiratory and saliva.[
]
References
External links
ICTV Report: ''Paramyxoviridae''
* http://www.biology-online.org/dictionary/Rubulavirus
Virus Pathogen Database and Analysis Resource (ViPR): Paramyxoviridae
*
{{Use dmy dates, date=April 2017
Mononegavirales
Paramyxoviridae
Rubulaviruses