Renal cell carcinoma with t(6;11) translocation or ''TFEB-amplified Renal Cell Carcinomas'' is rare subtype of

renal cell carcinoma Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the Proximal tubule, proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cance ...

. The t(6;11)(p21;q12) translocation fuses the Alpha (MALAT1) gene with the TFEB transcription factor gene, resulting in upregulated expression of TFEB which leads to expression of melanocytic markers.Pedram Argani, Victor E. Reuter, Lei Zhang, Yun-Shao Sung, Yi Ning, Jonathan I. Epstein, George J. Netto, and Cristina R. Antonescu: ''TFEB-amplified Renal Cell Carcinomas: An Aggressive Molecular Subset Demonstrating Variable Melanocytic Marker Expression and Morphologic Heterogeneity''. Am J Surg Pathol. 2016 Nov;40(11):1484-1495.

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Kidney cancer {{med-sign-stub