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Pain tolerance is the maximum level of
pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, ...
that a person is able to tolerate. Pain tolerance is distinct from
pain threshold The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. It is an entirely subjective phenomenon. A distinction must be maintained between the stimulus (an external ...
(the point at which pain begins to be felt)."IASP Taxonomy, Pain Terms".
Retrieved 4 December 2014
The
perception Perception () is the organization, identification, and interpretation of sensory information in order to represent and understand the presented information or environment. All perception involves signals that go through the nervous system ...
of pain that goes in to pain tolerance has two major components. First is the biological component—the headache or skin prickling that activates pain receptors. Second is the brain’s perception of pain—how much focus is spent paying attention to or ignoring the pain. The brain’s perception of pain is a response to signals from pain receptors that sensed the pain in the first place.


Factors


Sex

Clinical studies Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...
by the journal of ''Psychosomatic Medicine'' found that "men had higher pain thresholds and tolerances and lower pain ratings than women" when they are exposed to cold pressor pain. The study asked participants to submerge their hands in ice water (the cold pressor pain procedure) and told members of the
experimental group An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into Causality, cause-and-effect by demonstrating what outcome oc ...
(as opposed to the control group) that they would be compensated financially for keeping their hand submerged. Suggested explanations for this difference include, "men are more motivated to tolerate and suppress expressions of pain because of the masculine gender role, whereas the feminine gender role encourages pain expression and produces lower motivation to tolerate pain among women."


Passive or active support

A similar study published in the same books focused on the effects of having individuals perform the ice water procedure if they are accompanied by another participant. Their results revealed, "Participants in the active support and passive support conditions reported less pain than participants in the alone and interaction conditions, regardless of whether they were paired with a friend or stranger. These data suggest that the presence of an individual who provides passive or active support reduces experimental pain."


Age

Age and pain tolerance are relevant especially in the elderly because if their pain is detected too late, they run the risk of greater injury or delayed treatment of disease. However, current knowledge shows that pain tolerance does not show substantial change with age. Only
pain threshold The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. It is an entirely subjective phenomenon. A distinction must be maintained between the stimulus (an external ...
shows an effect: it increases with age.


Ethnicity

Although it is inconclusive whether pain tolerance differs by ethnicity, some studies have shown that non-Hispanic whites possess higher heat and cold pain tolerance when compared to African Americans and Hispanics.


Psychological factors

Patients with chronic
mood disorder A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where a disturbance in the person's mood is the main underlying feature. The classification is in the ''Diagnostic and Stat ...
s show an increased sensitivity to pain. This is not surprising because many of the brain pathways involved in depression are also involved in pain. These disorders weaken the cognitive aspect of pain and thus lower pain tolerance. These effects are worse in unipolar compared to
bipolar disorder Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that last from days to weeks each. If the elevated mood is severe or associated with ...
s, although both perceive pain significantly worse than people without a mood disorder. The lowest pain tolerance was seen in participants that were currently experiencing a
major depressive episode A major depressive episode (MDE) is a period characterized by the symptoms of major depressive disorder. Those affected primarily have a depressed mood for at least two weeks or more, and a loss of interest or pleasure in everyday activities. Other ...
. Lower pain tolerance associated with depressive symptoms can increase thoughts of suicide.


Hand dominancy, or handedness

One way to measure pain is to have participants place their hand in ice cold water. Their pain tolerance can then be measured based on how long they are able to keep their hand submerged before taking it out. One study used this technique to compare pain tolerance in dominant and non-dominant hands. One finding was that dominant hands showed a higher pain tolerance than non-dominant hands. Right-handers could withstand pain longer in their right hand than their left hand while the opposite was true for left-handers.


Neonatal injury

Nociceptive Nociception (also nocioception, from Latin ''nocere'' 'to harm or hurt') is the Somatosensory system, sensory nervous system's process of encoding Noxious stimulus, noxious stimuli. It deals with a series of events and processes required for an org ...
pathways are pathways in the brain that send and receive pain signals and are responsible for how we perceive pain. They develop before a baby is born and continue to develop during the
critical period In developmental psychology and developmental biology, a critical period is a maturational stage in the lifespan of an organism during which the nervous system is especially sensitive to certain environmental stimuli. If, for some reason, the org ...
of development. It was once thought that because infants’ nociceptive pathways in the brain were still developing, they could not feel pain. However, infants ''can'' feel pain and infant surgeries providing early pain experiences can alter the brain’s tolerance for pain later so by increasing number of A fibers and
C fibers Group C nerve fibers are one of three classes of nerve fiber in the central nervous system (CNS) and peripheral nervous system (PNS). The C group fibers are unmyelinated and have a small diameter and low conduction velocity, whereas Groups A ...
—two types of pain receptors—located in the area where injury occurred and by reducing pain tolerance in the areas where incision has occurred. This reduction in pain tolerance is seen in male rats even when they are adolescents. In those rats, the area of their brain where an incision was made as an infant remains hypersensitive to pain thereafter. This effect was not seen as prominently in female rats.


Association and disassociation

Association Association may refer to: *Club (organization), an association of two or more people united by a common interest or goal *Trade association, an organization founded and funded by businesses that operate in a specific industry *Voluntary associatio ...
and
disassociation Dissociation, as a concept that has been developed over time, is a wide array of experiences, ranging from a mild emotional detachment from the immediate surroundings, to a more severe disconnection from physical and emotional experiences. The m ...
are two cognitive strategies have been found to increase pain tolerance.


Conditioning

It is widely believed that regular exposure to painful stimuli will increase pain tolerance, increasing the ability of the individual to handle pain by becoming more conditioned to it. However, in some cases, there is evidence to support the theory that greater exposure to pain will result in more painful future exposures. Repeated exposure bombards pain synapses with repetitive input, increasing their responsiveness to later stimuli, through a process similar to learning. Therefore, although the individual may learn cognitive methods of coping with pain, such methods may not be sufficient to cope with the boosted response to future painful stimuli.James W. Kalat ''Biological Psychology'', 9th edition, 2007, p. 212. A mouse model study on the role of protein kinase C gamma (
PRKCG Protein kinase C gamma type is an enzyme that in humans is encoded by the ''PRKCG'' gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. P ...
) in pain sensitization found that mice lacking the protein also lacked the neuropathic pain sensitization seen in normal animals. Thus, trauma victims (or patients in pain) are given painkillers (such as
morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a analgesic, pain medication, and is also commonly used recreational drug, recreationally, or to make ...
) as soon as possible to prevent pain
sensitization Sensitization is a non-associative learning process in which repeated administration of a stimulus results in the progressive amplification of a response. Sensitization often is characterized by an enhancement of response to a whole class of stim ...
. Kalat suggests that morphine should be taken before surgery; "People who begin taking morphine before surgery need less of it afterward."


See also

*
Endurance game An endurance game is a game where the object is to last as long as possible under some sort of stress. The stress might be physical pain, fear, social embarrassment or any other negative sensation. The important distinguishing feature of endura ...


References

{{Pain Pain