Partitioning defective 3 homolog is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''PARD3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.
upplied by OMIMref name="entrez"/>
Interactions
PARD3 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
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JAM2
Junctional adhesion molecule B is a protein that in humans is encoded by the ''JAM2'' gene. JAM2 has also been designated as CD322 (cluster of differentiation 322).
Function
Tight junctions represent one mode of cell-to-cell adhesion in endot ...
,
[
* ]JAM3
Junctional adhesion molecule C is a protein that in humans is encoded by the ''JAM3'' gene.
Gene
This gene is located on the long arm of chromosome 11 (11q25) on the Watson strand. It is 83,077 bases in length. The encoded protein is 310 amino ...
,PRKCI
Protein kinase C iota type is an enzyme that in humans is encoded by the ''PRKCI'' gene.
Function
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight membe ...
,PVRL3
Nectin-3, also known as nectin cell adhesion molecule 3, is a protein that in humans is encoded by the ''NECTIN3'' gene.
Nectin-3 belongs to the family of immunoglobulin(Ig)-like cellular adhesion molecules involved in Ca2+-independent cellular ...
.
References
Further reading
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