Pyridoxal 5'-phosphate Synthase (glutamine Hydrolyzing)
   HOME

TheInfoList



OR:

Pyridoxal 5′-phosphate synthase (glutamine hydrolysing) (EC 4.3.3.6, ''PdxST'') is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...
D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5′-phosphate-lyase. This enzyme catalyses the following
chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine \rightleftharpoons pyridoxal 5′-phosphate + L-
glutamate Glutamic acid (symbol Glu or E; known as glutamate in its anionic form) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a Essential amino acid, non-essential nutrient for humans, meaning that ...
+ 3 H2O + phosphate (overall reaction) ::(1a) L-glutamine + H2O \rightleftharpoons L-glutamate + NH3 ::(1b) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 \rightleftharpoons pyridoxal 5′-phosphate + 4 H2O +
phosphate Phosphates are the naturally occurring form of the element phosphorus. In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthop ...
The enzyme can also use ribulose 5-phosphate and
dihydroxyacetone phosphate Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is the anion with the formula HOCH2C(O)CH2OPO32-. This anion is involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis.Nelson, D. L.; Co ...
.


References


External links

* {{Portal bar, Biology, border=no EC 4.3.3