DNA ligase (NAD
+) (, ''polydeoxyribonucleotide synthase (NAD
+)'', ''polynucleotide ligase (NAD
+)'', ''DNA repair enzyme'', ''DNA joinase'', ''polynucleotide synthetase (nicotinamide adenine dinucleotide)'', ''deoxyribonucleic-joining enzyme'', ''deoxyribonucleic ligase'', ''deoxyribonucleic repair enzyme'', ''deoxyribonucleic joinase'', ''DNA ligase'', ''deoxyribonucleate ligase'', ''polynucleotide ligase'', ''deoxyribonucleic acid ligase'', ''polynucleotide synthetase'', ''deoxyribonucleic acid joinase'', ''DNA-joining enzyme'', ''polynucleotide ligase (nicotinamide adenine dinucleotide)'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name
A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivi ...
''poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: NAD
+ + (deoxyribonucleotide)
n + (deoxyribonucleotide)
m AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)
n+m
Catalyses the formation of a
phosphodiester
In chemistry, a phosphodiester bond occurs when exactly two of the hydroxyl groups () in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds. The "bond" involves this linkage . Discussion of phosphodiesters is d ...
at the site of a single-strand break in duplex DNA.
See also
*
DNA ligase
DNA ligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role in repairing single-strand breaks in duplex DNA in living organisms, but some forms (such ...
References
External links
*
EC 6.5.1
{{Genetics-stub