Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P
2 4-Ptase, type II PtdIns-4,5-P
2 4-Ptase, IpgD, PtdIns-4,5-P
2 4-phosphatase type I, PtdIns-4,5-P
2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name
A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivi ...
1-phosphatidyl-1
D-''myo''-inositol-4,5-bisphosphate 4-phosphohydrolase.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: 1-phosphatidyl-1
D-''myo''-inositol 4,5-bisphosphate + H
2O
1-phosphatidyl-1
D-''myo''-inositol 5-phosphate +
phosphate
Phosphates are the naturally occurring form of the element phosphorus.
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthop ...
This enzyme participates in one of the
mammalian
A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three ...
pathways for degradation of 1-phosphatidyl-1
D-''myo''-inositol 4,5-bisphosphate
tdIns(4,5)P2
References
External links
*
{{Portal bar, Biology, border=no
EC 3.1.3