Orthogonal Signal Correction (OSC) is a spectral preprocessing technique that removes variation from a data matrix X that is

orthogonal In mathematics, orthogonality (mathematics), orthogonality is the generalization of the geometric notion of ''perpendicularity''. Although many authors use the two terms ''perpendicular'' and ''orthogonal'' interchangeably, the term ''perpendic ...

to the response matrix Y. OSC was introduced by researchers at the University of Umea in 1998 and has since found applications in domains including

metabolomics Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerpri ...

References

Signal processing {{statistics-stub