Neuroligin-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''NLGN1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This gene encodes a member of the
neuroligin
Neuroligin (NLGN), a type I membrane protein, is a cell adhesion protein on the postsynaptic membrane that mediates the formation and maintenance of synapses between neurons. Neuroligins act as ligands for β-neurexins, which are cell ad ...
family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.
Interactions
NLGN1 has been shown to
interact
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with
NRXN1
Neurexin-1-alpha is a protein that in humans is encoded by the ''NRXN1'' gene.
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes o ...
and
DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the ''DLG4'' (discs large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAG ...
.
See also
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Neurexin
Neurexins (NRXN) are a family of presynaptic cell adhesion proteins that have roles in connecting neurons at the synapse. They are located mostly on the presynaptic membrane and contain a single transmembrane domain. The extracellular domain ...
s:
NRXN1
Neurexin-1-alpha is a protein that in humans is encoded by the ''NRXN1'' gene.
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes o ...
,
NRXN2
Neurexin-2-alpha is a protein that in humans is encoded by the ''NRXN2'' gene.
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes o ...
,
NRXN3
Neurexin-3-alpha is a protein that in humans is encoded by the ''NRXN3'' gene.
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes o ...
References
Further reading
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