Monoclonal Antibodies4

Monoclonality refers to the state of a line of cells that have been derived from a single clonal origin. Thus "monoclonal cells" can be said to form a single cloning#Cellular cloning, clone. The term ''monoclonal'' comes from the Ancient Greek ''monos'', meaning "alone" or "single", and ''klon'', meaning "twig".

The process of replication can occur ''in vivo'', or may be stimulated ''in vitro'' for laboratory manipulations. The use of the term typically implies that there is some method to distinguish between the cells of the original population from which the single ancestral cell is derived, such as a random genetic alteration, which is inherited by the progeny.

Common usages of this term include:
* Monoclonal antibody: A single Hybridoma technology, hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. In informal laboratory jargon, the monoclonal antibodies isolated from cell culture Precipitation (chemistry), supernatants of these hybridoma clones (hybridoma lines) are simply called ''monoclonals''.
* Monoclonal neoplasm (tumor): A single aberrant cell which has undergone carcinogenesis reproduces itself into a cancerous mass.
* Monoclonal plasma cell (also called plasma cell dyscrasia): A single aberrant plasma cell which has undergone carcinogenesis reproduces itself, which in some cases is cancerous.

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Biology terminology