Mithridate, also known as mithridatium, mithridatum, or mithridaticum, is a semi-mythical remedy with as many as 65 ingredients, used as an

antidote An antidote is a substance that can counteract a form of poisoning. The term ultimately derives from the Greek term φάρμακον ἀντίδοτον ''(pharmakon) antidoton'', "(medicine) given as a remedy". Antidotes for anticoagulants are s ...

for

poison Poison is a chemical substance that has a detrimental effect to life. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broa ...

ing, and said to have been created by Mithridates VI Eupator of Pontus in the 1st century BC. It was one of the most complex and highly sought-after drugs during the Middle Ages and

Renaissance The Renaissance ( , ) , from , with the same meanings. is a period in European history marking the transition from the Middle Ages to modernity and covering the 15th and 16th centuries, characterized by an effort to revive and surpass ideas ...

, particularly in Italy and France, where it was in continual use for centuries. An updated recipe called theriac (

Theriacum Andromachi Theriac or theriaca is a medical concoction originally labelled by the Greeks in the 1st century AD and widely adopted in the ancient world as far away as Persia, China and India via the trading links of the Silk Route. It was an alexipharmic, ...

) was known well into the 19th century.Mithridate
. Mithridate takes its name from its inventor, Mithridates VI, king of the ancient Anatolian

Kingdom of Pontus Pontus ( grc-gre, Πόντος ) was a Hellenistic kingdom centered in the historical region of Pontus and ruled by the Mithridatic dynasty (of Persian origin), which possibly may have been directly related to Darius the Great of the Achaemeni ...

(134 to 63 BC), who is said to have so fortified his body against poisons with antidotes and preservatives that when he tried to kill himself, he could not find any poison that would have an effect, and, according to some legends, had to ask a soldier to run him through with a sword. The recipe for the reputed antidote was found in his cabinet, written with his own hand, and was carried to Rome by

Pompey Gnaeus Pompeius Magnus (; 29 September 106 BC – 28 September 48 BC), known in English as Pompey or Pompey the Great, was a leading Roman general and statesman. He played a significant role in the transformation of ...

. It was translated into Latin by Pompey's freedman Lenaeus, and later improved upon by

Nero Nero Claudius Caesar Augustus Germanicus ( ; born Lucius Domitius Ahenobarbus; 15 December AD 37 – 9 June AD 68), was the fifth Roman emperor and final emperor of the Julio-Claudian dynasty, reigning from AD 54 un ...

's physician Andromachus and

Marcus Aurelius Marcus Aurelius Antoninus (Latin: áːɾkus̠ auɾέːli.us̠ antɔ́ːni.us̠ English: ; 26 April 121 – 17 March 180) was Roman emperor from 161 to 180 AD and a Stoic philosopher. He was the last of the rulers known as the Five Good ...

' physician

Galen Aelius Galenus or Claudius Galenus ( el, Κλαύδιος Γαληνός; September 129 – c. AD 216), often Anglicized as Galen () or Galen of Pergamon, was a Greek physician, surgeon and philosopher in the Roman Empire. Considered to be one of ...

. It likely underwent considerable alterations since the time of Mithridates. In the Middle Ages, mithridate was also used as part of a regimen to ward off potential threats of

plague Plague or The Plague may refer to: Agriculture, fauna, and medicine *Plague (disease), a disease caused by ''Yersinia pestis'' * An epidemic of infectious disease (medical or agricultural) * A pandemic caused by such a disease * A swarm of pes ...

. According to Simon Kellwaye (1593), one should "take a great Onyon, make a hole in the myddle of him, then fill the place with Mitridat or Triacle, and some leaues of

Rue ''Ruta graveolens'', commonly known as rue, common rue or herb-of-grace, is a species of ''Ruta'' grown as an ornamental plant and herb. It is native to the Balkan Peninsula. It is grown throughout the world in gardens, especially for its bluis ...

". Until as late as 1786, physicians in London could officially prescribe mithridate.''

Nature Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...

''. 14 September 1989. 115/1. According to historian Christopher Hill,

Oliver Cromwell Oliver Cromwell (25 April 15993 September 1658) was an English politician and military officer who is widely regarded as one of the most important statesmen in English history. He came to prominence during the 1639 to 1651 Wars of the Three Ki ...

took a large dose of mithridate as a precaution against the plague and found it cured his

acne Acne, also known as ''acne vulgaris'', is a long-term Cutaneous condition, skin condition that occurs when Keratinocyte, dead skin cells and Sebum, oil from the skin clog hair follicles. Typical features of the condition include comedo, black ...

. The term ''mithridate'' has come to refer to any generally all-purpose antidote.

Origins

Mithridates' father was assassinated by poisoning, according to some at his mother's orders. After this, Mithridates's mother held regency over

Pontus Pontus or Pontos may refer to: * Short Latin name for the Pontus Euxinus, the Greek name for the Black Sea (aka the Euxine sea) * Pontus (mythology), a sea god in Greek mythology * Pontus (region), on the southern coast of the Black Sea, in modern ...

until a male heir was of age. Mithridates was in competition with another brother, whom his mother favored, for the throne. Supposedly during his youth he began to suspect plots against him at his mother's orders and was aware of her likely connection with his father's death. He then, supposedly, began to notice pains during his meals, and suspected his mother had ordered small amounts of poison to be added to his food in order to cause his health to deteriorate while avoiding notice of intent to kill him slowly. After other assassination attempts, he fled into the wilderness. While in the wild it is said that he began consuming non-lethal levels of poisons and mixing many into a remedy to make him immune to many poisons. In keeping with most medical practices of his era, Mithridates' anti-poison routines included a religious component supervised by ''Agari'', or

Scythia Scythia (Scythian: ; Old Persian: ; Ancient Greek: ; Latin: ) or Scythica (Ancient Greek: ; Latin: ), also known as Pontic Scythia, was a kingdom created by the Scythians during the 6th to 3rd centuries BC in the Pontic–Caspian steppe. His ...

shaman Shamanism is a religious practice that involves a practitioner (shaman) interacting with what they believe to be a spirit world through altered states of consciousness, such as trance. The goal of this is usually to direct spirits or spiritu ...

s who never left his side.

Formulation

Aulus Cornelius Celsus Aulus Cornelius Celsus ( 25 BC 50 AD) was a Roman encyclopaedist, known for his extant medical work, ''De Medicina'', which is believed to be the only surviving section of a much larger encyclopedia. The ''De Medicina'' is a primary source on d ...

details one version of the antidote in ''

De Medicina ''De Medicina'' is a 1st-century medical treatise by Aulus Cornelius Celsus, a Roman encyclopedist and possibly (but not likely) a practicing physician. It is the only surviving section of a much larger encyclopedia; only small parts still survive ...

'' (ca. AD 30). A recent translation is as follows: "But the most famous antidote is that of Mithridates, which that king is said to have taken daily and by it to have rendered his body safe against danger from poison". It contained: *

costmary ''Tanacetum balsamita'' is a perennial temperate herb known as costmary, alecost, balsam herb, bible leaf, or mint geranium. Description Costmary is a perennial with oval serrated leaves and can grow up to high. During summer, it shows small, y ...

, 1–66 grams *

sweet flag ''Acorus calamus'' (also called sweet flag, sway or muskrat root, among many common names) is a species of flowering plant with psychoactive chemicals. It is a tall wetland monocot of the family Acoraceae, in the genus ''Acorus.'' Although us ...

, 20 grams *

hypericum ''Hypericum'' is a genus of flowering plants in the family Hypericaceae (formerly considered a subfamily of Clusiaceae). The genus has a nearly worldwide distribution, missing only from tropical lowlands, deserts and polar regions. Many ''Hype ...

, 8 grams *

Natural gum Natural gums are polysaccharides of natural origin, capable of causing a large increase in a solution's viscosity, even at small concentrations. They are mostly botanical gums, found in the woody elements of plants or in seed coatings. Human u ...

, 8 grams *

sagapenum Sagapenum (Greek language, Greek ''σᾰγάπηνον'', ''σικβινίτζα'' (Du Cange), ''σεραπίων''; Arabic language, Arabic ''sakbīnadj''; Latin language, Latin ''sagapenum'', ''sagapium'', ''seraphinum'' (Pharmacopoea Wirtenbergi ...

, 8 grams *

acacia ''Acacia'', commonly known as the wattles or acacias, is a large genus of shrubs and trees in the subfamily Mimosoideae of the pea family Fabaceae. Initially, it comprised a group of plant species native to Africa and Australasia. The genus na ...

juice, 8 grams *Illyrian

iris Iris most often refers to: *Iris (anatomy), part of the eye *Iris (mythology), a Greek goddess * ''Iris'' (plant), a genus of flowering plants * Iris (color), an ambiguous color term Iris or IRIS may also refer to: Arts and media Fictional ent ...

(probably ''I. germanica''), 8 grams *

cardamom Cardamom (), sometimes cardamon or cardamum, is a spice made from the seeds of several plants in the genera ''Elettaria'' and ''Amomum'' in the family Zingiberaceae. Both genera are native to the Indian subcontinent and Indonesia. They are rec ...

, 8 grams *

anise Anise (; '), also called aniseed or rarely anix is a flowering plant in the family Apiaceae native to Eurasia. The flavor and aroma of its seeds have similarities with some other spices and herbs, such as star anise, fennel, licorice, and ta ...

, 12 grams *Gallic nard (''

Valeriana ''Valeriana'' is a genus of flowering plants in the family Caprifoliaceae, members of which may by commonly known as valerians. It contains many species, including the garden valerian, ''Valeriana officinalis''. Species are native to all continen ...

italica''), 16 grams *

gentian ''Gentiana'' is a genus of flowering plants belonging to the gentian family (Gentianaceae), the tribe Gentianeae, and the monophyletic subtribe Gentianinae. With about 400 species it is considered a large genus. They are notable for their mostl ...

root, 16 grams *dried

rose A rose is either a woody perennial flowering plant of the genus ''Rosa'' (), in the family Rosaceae (), or the flower it bears. There are over three hundred species and tens of thousands of cultivars. They form a group of plants that can be ...

leaves, 16 grams *

poppy A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae. Poppies are herbaceous plants, often grown for their colourful flowers. One species of poppy, ''Papaver somniferum'', is the source of the narcotic drug opi ...

-tears (''

Papaver rhoeas ''Papaver rhoeas'', with common names including common poppy, corn poppy, corn rose, field poppy, Flanders poppy, and red poppy, is an annual herbaceous species of flowering plant in the poppy family Papaveraceae. It is a temperate native with ...

'', a wild poppy with low opiate content),Stata Norton, Molecular Interventions 6:60–66, 2006
/ref> 17 grams *

parsley Parsley, or garden parsley (''Petroselinum crispum'') is a species of flowering plant in the family Apiaceae that is native to the central and eastern Mediterranean region (Sardinia, Lebanon, Israel, Cyprus, Turkey, southern Italy, Greece, Por ...

, 17 grams * casia, 20–66 grams *

saxifrage ''Saxifraga'' is the largest genus in the family Saxifragaceae, containing about 465 species of holarctic perennial plants, known as saxifrages or rockfoils. The Latin word ''saxifraga'' means literally "stone-breaker", from Latin ' ("rock" or " ...

, 20–66 grams *

darnel ''Lolium temulentum'', typically known as darnel, poison darnel, darnel ryegrass or cockle, is an annual plant of the genus '' Lolium'' within the family Poaceae. The plant stem can grow up to one meter tall, with inflorescence in the ears and p ...

, 20–66 grams *

long pepper Long pepper (''Piper longum''), sometimes called Indian long pepper or ''thippali'', is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. Long pepper has a taste simil ...

, 20–66 grams *

storax Storax ( la, storax; el, στύραξ, ''stúrax''), often commercially sold as styrax, is a natural resin isolated from the wounded bark of ''Liquidambar orientalis'' Mill. (Asia Minor) and ''Liquidambar styraciflua'' L. (Central America) (Ham ...

, 21 grams *

castoreum Castoreum is a yellowish exudate from the castor sacs of mature beavers. Beavers use castoreum in combination with urine to scent mark their territory. Both beaver sexes have a pair of castor sacs and a pair of anal glands, located in two cavities ...

, 24 grams *

frankincense Frankincense (also known as olibanum) is an aromatic resin used in incense and perfumes, obtained from trees of the genus ''Boswellia'' in the family Burseraceae. The word is from Old French ('high-quality incense'). There are several species o ...

, 24 grams * hypocistis juice, 24 grams *

myrrh Myrrh (; from Semitic, but see '' § Etymology'') is a gum-resin extracted from a number of small, thorny tree species of the genus ''Commiphora''. Myrrh resin has been used throughout history as a perfume, incense and medicine. Myrrh mi ...

, 24 grams * opopanax, 24 grams *

malabathrum Malabathrum, malabathron, or malobathrum is the name used in classical and medieval texts for certain cinnamon-like aromatic plant leaves and an ointment prepared from those leaves. '' Cinnamomum tamala'' (sometimes given as ''Cinnamomum tejpa ...

leaves, 24 grams *flower of round rush, 24–66 grams *

turpentine Turpentine (which is also called spirit of turpentine, oil of turpentine, terebenthene, terebinthine and (colloquially) turps) is a fluid obtained by the distillation of resin harvested from living trees, mainly pines. Mainly used as a special ...

-resin, 24–66 grams *

galbanum Galbanum is an aromatic gum resin and a product of certain umbelliferous Persian plant species in the genus ''Ferula'', chiefly ''Ferula gummosa'' (synonym ''F. galbaniflua'') and ''Ferula rubricaulis''. Galbanum-yielding plants grow plentifull ...

, 24–66 grams *Cretan carrot seeds, 24–66 grams * nard, 25 grams * opobalsam, 25 grams *

shepherd's purse ''Capsella bursa-pastoris'', known as shepherd's purse because of its triangular flat fruits, which are purse-like, is a small annual and ruderal flowering plant in the mustard family (Brassicaceae). It is native to eastern Europe and Asia minor, ...

, 25 grams *

rhubarb Rhubarb is the fleshy, edible stalks ( petioles) of species and hybrids (culinary rhubarb) of ''Rheum'' in the family Polygonaceae, which are cooked and used for food. The whole plant – a herbaceous perennial growing from short, thick rhizo ...

root, 28 grams *

saffron Saffron () is a spice derived from the flower of ''Crocus sativus'', commonly known as the "saffron crocus". The vivid crimson stigma and styles, called threads, are collected and dried for use mainly as a seasoning and colouring agent i ...

, 29 grams *

ginger Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice A spice is a seed, fruit, root, bark, or other plant substance primarily used for flavoring or coloring food. Spices ...

, 29 grams *

cinnamon Cinnamon is a spice obtained from the inner bark of several tree species from the genus ''Cinnamomum''. Cinnamon is used mainly as an aromatic condiment and flavouring additive in a wide variety of cuisines, sweet and savoury dishes, breakfa ...

, 29 grams The ingredients are then "pounded and taken up in

honey Honey is a sweet and viscous substance made by several bees, the best-known of which are honey bees. Honey is made and stored to nourish bee colonies. Bees produce honey by gathering and then refining the sugary secretions of plants (primar ...

. Against poisoning, a piece the size of an

almond The almond (''Prunus amygdalus'', syn. ''Prunus dulcis'') is a species of tree native to Iran and surrounding countries, including the Levant. The almond is also the name of the edible and widely cultivated seed of this tree. Within the genus ...

is given in wine. In other affections an amount corresponding in size to an Egyptian bean is sufficient." Of these ingredients, Illyrian iris, darnel, and rhubarb were not commonly found in other versions of the antidote. However, Celsus' formulation, written 100 years after the death of Mithridates, was one of the first published. Galen called the antidote "

theriac Theriac or theriaca is a medical concoction originally labelled by the Greeks in the 1st century AD and widely adopted in the ancient world as far away as Persia, China and India via the trading links of the Silk Route. It was an alexipharmic, ...

" and presented versions by Aelius (used by Julius Caesar), Andromachus (physician to Nero), Antipater, Nicostratus, and Damocratis. The Andromachus formulation closely resembles that of Celsus. The manufacture of antidotes called mithridate or

(English "treacle") continued into the nineteenth century.

Ephraim Chambers Ephraim Chambers ( – 15 May 1740) was an English writer and encyclopaedist, who is primarily known for producing the '' Cyclopaedia, or a Universal Dictionary of Arts and Sciences''. Biography Chambers was born in Milton near Kendal, Westmor ...

, in his 1728 Cyclopaedia, says "Mithridate is one of the capital Medicines in the Apothecaries Shops, being composed of a vast Number of Drugs, as

Opium Opium (or poppy tears, scientific name: ''Lachryma papaveris'') is dried latex obtained from the seed capsules of the opium poppy ''Papaver somniferum''. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which i ...

Myrrh Myrrh (; from Semitic, but see '' § Etymology'') is a gum-resin extracted from a number of small, thorny tree species of the genus ''Commiphora''. Myrrh resin has been used throughout history as a perfume, incense and medicine. Myrrh mi ...

Agaric An agaric () is a type of fungus fruiting body characterized by the presence of a pileus (cap) that is clearly differentiated from the stipe (stalk), with lamellae (gills) on the underside of the pileus. In the UK, agarics are called "mushrooms ...

Saffron Saffron () is a spice derived from the flower of ''Crocus sativus'', commonly known as the "saffron crocus". The vivid crimson stigma and styles, called threads, are collected and dried for use mainly as a seasoning and colouring agent i ...

Ginger Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice A spice is a seed, fruit, root, bark, or other plant substance primarily used for flavoring or coloring food. Spices ...

Cinnamon Cinnamon is a spice obtained from the inner bark of several tree species from the genus ''Cinnamomum''. Cinnamon is used mainly as an aromatic condiment and flavouring additive in a wide variety of cuisines, sweet and savoury dishes, breakfa ...

Spikenard Spikenard, also called nard, nardin, and muskroot, is a class of aromatic amber-colored essential oil derived from ''Nardostachys jatamansi'', a flowering plant in the honeysuckle family which grows in the Himalayas of Nepal, China, and India. Th ...

Frankincense Frankincense (also known as olibanum) is an aromatic resin used in incense and perfumes, obtained from trees of the genus ''Boswellia'' in the family Burseraceae. The word is from Old French ('high-quality incense'). There are several species o ...

, Castor,

Pepper Pepper or peppers may refer to: Food and spice * Piperaceae or the pepper family, a large family of flowering plant ** Black pepper * ''Capsicum'' or pepper, a genus of flowering plants in the nightshade family Solanaceae ** Bell pepper ** Chili ...

Gentian ''Gentiana'' is a genus of flowering plants belonging to the gentian family (Gentianaceae), the tribe Gentianeae, and the monophyletic subtribe Gentianinae. With about 400 species it is considered a large genus. They are notable for their mostl ...

, &c. It is accounted a Cordial,

Opiate An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term ''opioid'' is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonis ...

Sudorific Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals. Two types of sweat glands can be found in humans: eccrine glands and apocrine glands. The eccrine sweat glands are distribu ...

, and

Alexipharmic An antidote is a substance that can counteract a form of poisoning. The term ultimately derives from the Greek term φάρμακον ἀντίδοτον ''(pharmakon) antidoton'', "(medicine) given as a remedy". Antidotes for anticoagulants are ...

". Petrus Andreas Matthiolus considered it more effectual against poisons than

Venice treacle Theriac or theriaca is a medical concoction originally labelled by the Greeks in the 1st century AD and widely adopted in the ancient world as far away as Persia, China and India via the trading links of the Silk Route. It was an alexipharmic, ...

, and easier to make. Late versions of the antidote incorporated dried blood or the dried flesh of lizards or

viper The Viperidae (vipers) are a family of snakes found in most parts of the world, except for Antarctica, Australia, Hawaii, Madagascar, and various other isolated islands. They are venomous and have long (relative to non-vipers), hinged fangs tha ...

s or

Malabathrum Malabathrum, malabathron, or malobathrum is the name used in classical and medieval texts for certain cinnamon-like aromatic plant leaves and an ointment prepared from those leaves. '' Cinnamomum tamala'' (sometimes given as ''Cinnamomum tejpa ...

Dunglison, Robley. 1848. ''Medical lexicon. A dictionary of medical science''.

Criticism

Pliny Pliny may refer to: People * Pliny the Elder (23–79 CE), ancient Roman nobleman, scientist, historian, and author of ''Naturalis Historia'' (''Pliny's Natural History'') * Pliny the Younger (died 113), ancient Roman statesman, orator, w ...

('' Natural History'', XXIX.24–25, ca. AD 77) was skeptical of mithridate and other such

s (panacea potions), with their numerous ingredients:

In literature

A. E. Housman Alfred Edward Housman (; 26 March 1859 – 30 April 1936) was an English classical scholar and poet. After an initially poor performance while at university, he took employment as a clerk in London and established his academic reputation by pub ...

's collection of poetry titled '' A Shropshire Lad'' published in 1896, there is a poem about King Mithridates and his antidote's amazing abilities:

References

{{Opioidergics Traditional medicine

Origins

Formulation

Criticism

In literature

See also

References