MOPP is a
combination chemotherapy regimen used to treat
Hodgkin lymphoma. The acronym is derived from the component drugs of the regimen:
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Mustargen (also known as mechlorethamine, chlormethine, mustine, nitrogen mustard, or MSD)
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Oncovin (also known as vincristine or VCR)
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Procarbazine
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Prednisone
Prednisone is a glucocorticoid medication mostly used to immunosuppressive drug, suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium ...
Process
Mechlorethamine and vincristine are administered
intravenous
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutr ...
ly, while procarbazine and prednisone are pills taken orally. A newer Hodgkin lymphoma treatment is
ABVD.
C-MOPP involves switching the
nitrogen mustard from mechlorethamine to
cyclophosphamide. C-MOPP is thus very similar to
COPP, using the same four agents and differing at most in dosages and timing.
History
MOPP was the first combination chemotherapy that achieved a high success rate. It was developed at the
National Cancer Institute.
Although no longer the most effective combination, MOPP is still used after relapse or where the patient has certain
allergies
Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
or
lung
The lungs are the primary Organ (biology), organs of the respiratory system in many animals, including humans. In mammals and most other tetrapods, two lungs are located near the Vertebral column, backbone on either side of the heart. Their ...
or
heart
The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrie ...
problems which prevents the use of another regimen.
Side effects
There is 20% chance of developing a second cancer within 20 years of MOPP treatment. As a result, MOPP is rarely used for treatment for Hodgkin lymphoma.
Hodgkin's Chemtherapy - MOPP
/ref> MOPP has been known to cause alopecia (hair loss) and skin sensitivity (especially to sunlight). Nausea, vomiting
Vomiting (also known as emesis, puking and throwing up) is the forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.
Vomiting can be the result of ailments like food poisoning, gastroenteritis, pre ...
, and stomach ache are common, as are chills, constipation, and frequent urination
Urination is the release of urine from the bladder through the urethra in Placentalia, placental mammals, or through the cloaca in other vertebrates. It is the urinary system's form of excretion. It is also known medically as micturition, v ...
. Permanent sterility is a frequent side effect.
See also
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References
{{Chemotherapeutic Agents
Hodgkin lymphoma
IARC Group 1 carcinogens
Chemotherapy regimens used in lymphoma