Monooxygenases are enzymes that incorporate one
hydroxyl group (−OH) into substrates in many metabolic pathways. In this reaction, the two atoms of
dioxygen are reduced to one
hydroxyl group and one H
2O molecule by the concomitant oxidation of
NAD(P)H.
One important subset of the monooxygenases, the
cytochrome P450 omega hydroxylases, is used by cells to metabolize arachidonic acid (i.e. eicosatetraenoic acid) to the
cell signaling molecules,
20-hydroxyeicosatetraenoic acid or to reduce or totally inactivate the activate signaling molecules for example by hydroxylating
leukotriene B4 to 20-hydroxy-leukotriene B5,
5-hydroxyeicosatetraenoic acid to 5,20-dihydroxyeicosatetraenoic acid,
5-oxo-eicosatetraenoic acid to 5-oxo-20-hydroxyeicosatetraenoic acid,
12-hydroxyeicosatetraenoic acid to 12,20-dihydroxyeicosatetraenoic acid, and
epoxyeicosatrienoic acids to 20-hydroxy-epoxyeicosatrienoic acids.
Classification
They are classified as
oxidoreductase
In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually ...
enzymes that catalyzes an electron transfer.
Related structures2XDO2XYO2Y6R
Human proteins containing this domain
COQ6; CYP450; MICAL1; MICAL2; MICAL2PV1; MICAL2PV2; MICAL3;
See also
* ABM domain
References
External links
*
{{Oxygenases
Protein domains
Enzymes