Max Tishler (October 30, 1906 – March 18, 1989) was president of Merck Sharp and Dohme Research Laboratories where he led the research teams that synthesized

ascorbic acid Ascorbic acid is an organic compound with formula , originally called hexuronic acid. It is a white solid, but impure samples can appear yellowish. It dissolves freely in water to give mildly acidic solutions. It is a mild reducing agent. Asco ...

riboflavin Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement. It is essential to the formation of two major coenzymes, flavin mononucleotide and flavin adenine dinucleotide. These coenzymes are involved in ...

cortisone Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug. Cortisol is converted by the action of the enzyme corticosteroid 11-beta-dehydrogenase ...

pyridoxine Pyridoxine (PN) is a form of vitamin B6 found commonly in food and used as a dietary supplement. As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metaboli ...

pantothenic acid Pantothenic acid (vitamin B5) is a B vitamin and an essential nutrient. All animals need pantothenic acid in order to synthesize coenzyme A (CoA), which is essential for cellular energy production and for the synthesis and degradation of prote ...

nicotinamide Nicotinamide (International nonproprietary name, INN, British Approved Name, BAN ) or niacinamide (United States Adopted Name, USAN ) is a form of vitamin B3, vitamin B3 found in food and used as a dietary supplement and medication. As a suppl ...

methionine Methionine (symbol Met or M) () is an essential amino acid in humans. As the precursor of other non-essential amino acids such as cysteine and taurine, versatile compounds such as SAM-e, and the important antioxidant glutathione, methionine play ...

threonine Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form when dissolved in water), a carboxyl group (which is in the deprotonated −COO− ...

, and

tryptophan Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins. Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromat ...

. He also developed the

fermentation Fermentation is a type of anaerobic metabolism which harnesses the redox potential of the reactants to make adenosine triphosphate (ATP) and organic end products. Organic molecules, such as glucose or other sugars, are catabolized and reduce ...

processes for actinomycin, vitamin B₁₂,

streptomycin Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium avium complex, ''Mycobacterium avium'' complex, endocarditis, brucellosis, Burkholderia infection, ''Burkholderia'' i ...

, and

penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...

. Tishler invented sulfaquinoxaline for the treatment for

coccidiosis Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The disease spreads from one animal to another by contact with infected feces or ingestion of infected tissue. Diarrhea, which may become bloody ...

Biography

He was born in

Boston, Massachusetts Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...

on October 30, 1906. His father repaired shoes and he abandoned the family in 1911. Max worked in a pharmacy during the flu pandemic of 1918. He studied chemistry as an undergraduate at

Tufts College Tufts University is a Private university, private research university in Medford, Massachusetts, Medford and Somerville, Massachusetts, United States, with additional facilities in Boston and Grafton, Massachusetts, Grafton, as well as Talloire ...

, where he was a member of the Pi Lambda Phi

fraternity A fraternity (; whence, "wikt:brotherhood, brotherhood") or fraternal organization is an organization, society, club (organization), club or fraternal order traditionally of men but also women associated together for various religious or secular ...

. In 1934 he earned his Ph.D. in

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain ...

from

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

. He married Elizabeth M. Verveer in 1934. He taught at Harvard from 1934 to 1937. His son, Peter Verveer Tishler, was born on July 18, 1937. In 1937, he took a position at Merck. His first project at Merck was to produce

. In the 1940s he developed a process for the synthesis of

. In 1970 he retired from Merck, and taught chemistry at

Wesleyan University Wesleyan University ( ) is a Private university, private liberal arts college, liberal arts university in Middletown, Connecticut, United States. It was founded in 1831 as a Men's colleges in the United States, men's college under the Methodi ...

. He died of

emphysema Emphysema is any air-filled enlargement in the body's tissues. Most commonly emphysema refers to the permanent enlargement of air spaces (alveoli) in the lungs, and is also known as pulmonary emphysema. Emphysema is a lower respiratory tract di ...

at Middlesex Memorial Hospital in

Middletown, Connecticut Middletown is a city in Middlesex County, Connecticut, United States. Located along the Connecticut River, in the central part of the state, 16 miles (25.749504 km) south of Hartford, Connecticut, Hartford. Middletown is the largest city in the L ...

on March 18, 1989.

Education

*B.S. Chemistry,

, 1928, magna cum laude *M.A. Chemistry,

, 1933 *Ph.D. Organic Chemistry,

, 1934 :Research Advisor: Elmer P. Kohler, Dissertation title: "I. The reduction of alpha halo-ketones. II. The action of organic magnesium halides on alpha halo-ketones and on alpha halo-sulfones."

Honors

* Chemical Pioneer Award (1968) * Priestley Medal (1970) *

American Institute of Chemists Gold Medal The American Institute of Chemists Gold Medal is the highest award of the American Institute of Chemists and has been awarded since 1926. It is presented annually to a person who has most encouraged the science of chemistry or the profession of ...

(1977) *

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral science, behavior ...

National Inventors Hall of Fame The National Inventors Hall of Fame (NIHF) is an American not-for-profit organization, founded in 1973, which recognizes individual engineers and inventors who hold a US patent of significant technology. Besides the Hall of Fame, it also operate ...

* IRI Medal

References

Wesleyan University faculty 20th-century American chemists National Medal of Science laureates Harvard University alumni 1906 births 1989 deaths Scientists from Boston Tufts University alumni 20th-century American inventors {{US-chemist-stub