Mark Quayle may refer to:
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Mark Quayle (advocate, b. 1770) KC, (1770–1804), Clerk of the Rolls of the Isle of Man
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Mark Quayle (advocate, b. 1804) QC, (1804–1879), Clerk of the Rolls of the Isle of Man and Member of the House of Keys
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Mark Quayle (advocate, b. 1841) QC, (1841–1928), Manx-born advocate and businessman
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Mark Quayle (footballer) (born 1978), association footballer
{{hndis, Quayle, Mark