Stéphane Marcel Delépine (19 September 1871, in

Saint-Martin-le-Gaillard Saint-Martin-le-Gaillard () is a commune in the Seine-Maritime department in the Normandy region in northern France. Geography A farming village situated by the banks of the river Yères in the Pays de Caux, at the junction of the D16 and the ...

– 21 September 1965) was a French pharmacist and chemist, whose name is associated with the

Delépine reaction The Delépine reaction is the organic synthesis of primary amines (4) by reaction of benzyl or alkyl halides (1) with hexamethylenetetramine (2) followed by acid hydrolysis of the quaternary ammonium salt (3). It is named after the French chemist S ...

for the preparation of

primary amines In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed when one or more hydrogen atoms in ammonia are replaced by alkyl or aryl groups. The nitrogen atom in an amine possesses a lone pair of elec ...

. He studied at the Sorbonne and at the École Supérieure de Pharmacie in

Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, largest city of France. With an estimated population of 2,048,472 residents in January 2025 in an area of more than , Paris is the List of ci ...

, receiving his doctorate in 1898 with the thesis ''Amines et amides dérivés des aldéhydes'' ("The

amine In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed when one or more hydrogen atoms in ammonia are replaced by alkyl or aryl groups. The nitrogen atom in an amine possesses a lone pair of elec ...

s and

amide In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a chemical compound, compound with the general formula , where R, R', and R″ represent any group, typically organyl functional group, groups or hydrogen at ...

derivatives of

aldehyde In organic chemistry, an aldehyde () (lat. ''al''cohol ''dehyd''rogenatum, dehydrogenated alcohol) is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred ...

s"). From 1895 to 1902 he served as ''préparateur'' at the

Collège de France The (), formerly known as the or as the ''Collège impérial'' founded in 1530 by François I, is a higher education and research establishment () in France. It is located in Paris near La Sorbonne. The has been considered to be France's most ...

, where he worked in the laboratory of

Marcellin Berthelot Pierre Eugène Marcellin Berthelot (; 25 October 1827 – 18 March 1907) was a French chemist and Republican politician noted for the ThomsenBerthelot principle of thermochemistry. He synthesized many organic compounds from inorganic substance ...

. In 1902 he was named chief pharmacist to the hospitals of Paris, a position he maintained up until 1927.Stéphane Marcel Delépine
Société d'Histoire de la Pharmacie From 1904 he was an '' agrégé'' at the École Supérieure de Pharmacie, attaining the chair of

hydrology Hydrology () is the scientific study of the movement, distribution, and management of water on Earth and other planets, including the water cycle, water resources, and drainage basin sustainability. A practitioner of hydrology is called a hydro ...

and hygiene in 1913. In 1930 he was appointed a professor of

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain ...

at the Collège de France.Sociétés savantes de France
(biography) In 1927 he became a scientific advisor for Etablissements Poulenc, and subsequently was named director of pharmaceutical research for

Rhône-Poulenc Rhône-Poulenc () was a French chemical and pharmaceutical company founded in 1928. In 1999, it merged with Hoechst AG to form Aventis. As of 2015, the pharmaceutical operations of Rhône-Poulenc are part of Sanofi and the chemicals divisions ...

. In 1930 he became a member of the

Académie des sciences The French Academy of Sciences (, ) is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French Scientific method, scientific research. It was at the forefron ...

. His work involved research in the fields of organic, inorganic and general chemistry. He made contributions in his investigations of

terpene Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n ≥ 2. Terpenes are major biosynthetic building blocks. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predomi ...

platinum group metals The platinum-group metals (PGMs) are six noble, precious metallic elements clustered together in the periodic table. These elements are all transition metals in the d-block (groups 8, 9, and 10, periods 5 and 6). The six platinum-group m ...

(

iridium Iridium is a chemical element; it has the symbol Ir and atomic number 77. This very hard, brittle, silvery-white transition metal of the platinum group, is considered the second-densest naturally occurring metal (after osmium) with a density ...

rhodium Rhodium is a chemical element; it has symbol Rh and atomic number 45. It is a very rare, silvery-white, hard, corrosion-resistant transition metal. It is a noble metal and a member of the platinum group. It has only one naturally occurring isot ...

sulfur compounds Sulfur compounds are chemical compounds formed the element sulfur (S). Common oxidation states of sulfur range from −2 to +6. Sulfur forms stable compounds with all elements except the noble gases. Electron transfer reactions Sulfur polyca ...

, et al. In 1935 he described a general method for

catalytic hydrogenation Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic ...

with

Raney nickel Raney nickel , also called spongy nickel, is a fine-grained solid composed mostly of nickel derived from a nickel–aluminium alloy. Several grades are known, of which most are gray solids. Some are pyrophoric, but most are used as air-stable s ...

. Also, when experimenting with thiocarbonic esters and related bodies, he discovered the phenomena of "oxyluminescence". In addition, he is credited for introducing a new process for preparation of pure

tungsten Tungsten (also called wolfram) is a chemical element; it has symbol W and atomic number 74. It is a metal found naturally on Earth almost exclusively in compounds with other elements. It was identified as a distinct element in 1781 and first ...

Selected works

* ''Composés endothermiques et exothermiques'', 1899 –

Endothermic An endothermic process is a chemical or physical process that absorbs heat from its surroundings. In terms of thermodynamics, it is a thermodynamic process with an increase in the enthalpy (or internal energy ) of the system.Oxtoby, D. W; Gillis, ...

and

exothermic In thermodynamics, an exothermic process () is a thermodynamic process or reaction that releases energy from the system to its surroundings, usually in the form of heat, but also in a form of light (e.g. a spark, flame, or flash), electricity (e ...

compounds. * ''Carbures métalliques'', 1904 – Metal

carbide In chemistry, a carbide usually describes a compound composed of carbon and a metal. In metallurgy, carbiding or carburizing is the process for producing carbide coatings on a metal piece. Interstitial / Metallic carbides The carbides of th ...

s. * ''La synthèse totale en chimie organique'', 1937 – The total synthesis in organic chemistry. * ''Chimie organique. Formules de constitution, isomérie, isomérie optique'', 1937 – Organic chemistry; constitutional formulas,

isomerism In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element (chemistry), element – but distinct arrangements of atoms in space. ''Isomerism'' refers to the exi ...

optical isomerism In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...

. * ''Un Grand chimiste analyste : Louis-Nicolas Vauquelin'', 1941 – The great analytical chemist,

Louis-Nicolas Vauquelin Louis Nicolas Vauquelin FRS(For) HFRSE (; 16 May 1763 – 14 November 1829) was a French pharmacist and chemist. He was the discoverer of chromium and beryllium. Early life Vauquelin was born at Saint-André-d'Hébertot in Normandy, France, th ...

.Most widely held works by Marcel Delépine
WorldCat Identities * '' Vie et œuvre de Joseph Achille Le Bel'', 1949 – The life and work of

Joseph Achille Le Bel Joseph Achille Le Bel (21 January 1847 in Pechelbronn – 6 August 1930, in Paris, France) was a French chemist. He is best known for his work in stereochemistry. Le Bel was educated at the École Polytechnique in Paris. In 1874 he announced his ...

References

{{DEFAULTSORT:Delépine, Marcel 1871 births 1965 deaths People from Seine-Maritime Academic staff of the Collège de France 20th-century French chemists French pharmacists