Mannosyl-oligosaccharide 1,2-alpha-mannosidase (, ''mannosidase 1A'', ''mannosidase 1B'', ''1,2-alpha-mannosidase'', ''exo-alpha-1,2-mannanase'', ''mannose-9 processing alpha-mannosidase'', ''glycoprotein processing mannosidase I'', ''mannosidase I'', ''Man9-mannosidase'', ''ManI'', ''1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase'') is an enzyme with systematic name ''2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase''. This enzyme catalyses the following chemical reaction : Hydrolysis of the terminal (1->2)-linked alpha-D- mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 This enzyme is involved in the synthesis of glycoproteins.

Kifunensine Kifunensine is an alkaloid originally isolated from ''Kitasatosporia kifunense'', an actinobacterium (formerly called an actinomycete). It is a neutral, stable compound. Kifunensine is a potent inhibitor of the mannosidase I enzyme and is primar ...

is a potent inhibitor of mannosidase I.

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External links

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