Mannosyl-oligosaccharide 1,2-a-mannosidase
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Mannosyl-oligosaccharide 1,2-α-mannosidase (, ''mannosidase 1A'', ''mannosidase 1B'', ''1,2-α-mannosidase'', ''exo-α-1,2-mannanase'', ''mannose-9 processing α-mannosidase'', ''glycoprotein processing mannosidase I'', ''mannosidase I'', ''Man9-mannosidase'', ''ManI'', ''1,2-α-mannosyl-oligosaccharide α-D-mannohydrolase'') is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...
''2-α-mannosyl-oligosaccharide α-D-mannohydrolase''. It catalyses the
hydrolysis Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water ...
of the terminal (1→2)-linked α-D-
mannose Mannose is a sugar with the formula , which sometimes is abbreviated Man. It is one of the monomers of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylatio ...
residues in the oligo-mannose
oligosaccharide An oligosaccharide (; ) is a carbohydrate, saccharide polymer containing a small number (typically three to ten) of monosaccharides (simple sugars). Oligosaccharides can have many functions including Cell–cell recognition, cell recognition and ce ...
Man9(GlcNAc)2. This enzyme is involved in the synthesis of
glycoproteins Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known a ...
. Kifunensine is a potent inhibitor of mannosidase I.


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* {{Portal bar, Biology, border=no EC 3.2.1