The Lander–Green algorithm is an algorithm, due to

Eric Lander Eric Steven Lander (born February 3, 1957) is an American mathematician and geneticist who served as the 11th director of the Office of Science and Technology Policy and Science Advisor to the President, serving on the presidential Cabinet. Lan ...

and

Philip Green Sir Philip Nigel Ross Green (born 15 March 1952) is a British businessman who was the chairman of the retail company the Arcadia Group. He owned the high street clothing retailers Topshop, Topman and Miss Selfridge from 2002 to 2020. As of Ma ...

for computing the

likelihood The likelihood function (often simply called the likelihood) represents the probability of random variable realizations conditional on particular values of the statistical parameters. Thus, when evaluated on a given sample, the likelihood funct ...

of observed genotype data given a pedigree. It is appropriate for relatively small pedigrees and a large number of markers. It is used in the analysis of

genetic linkage Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Two genetic markers that are physically near to each other are unlikely to be separ ...

.Lander, E.S. and Green, P. (1987
"Construction of multilocus genetic linkage maps in humans"
''Proceedings of the National Academy of Sciences'', 84 (8), 2363–2367 Abecasis, G.R., Wigginton, J.E. (2005
"Handling Marker-Marker Linkage Disequilibrium: Pedigree Analysis with Clustered Markers"
''Am J Hum Genet.'', 77(5), 754–767.

References

Genetic epidemiology Statistical genetics Genetic linkage analysis Statistical algorithms {{statistics-stub