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Louise Joy Brown (born 25 July 1978) is an English woman noted as the first human born following conception by
in vitro fertilisation In vitro fertilisation (IVF) is a process of fertilisation in which an ovum, egg is combined with spermatozoon, sperm in vitro ("in glass"). The process involves monitoring and stimulating the Ovulation cycle, ovulatory process, then removing ...
(IVF). Her birth, following a procedure pioneered in Britain, has been lauded among "the most remarkable medical breakthroughs of the 20th century".


Life

Brown's parents, Lesley and John Brown, had been trying to conceive naturally for nine years but Lesley faced complications from blocked fallopian tubes."World's first IVF baby marks 30th birthday"
Agence France-Presse Agence France-Presse (; AFP) is a French international news agency headquartered in Paris, France. Founded in 1835 as Havas, it is the world's oldest news agency. With 2,400 employees of 100 nationalities, AFP has an editorial presence in 260 c ...
, 23 July 2008. Retrieved 24 July 2008.
On 10 November 1977, Lesley underwent the procedure that later became known as
in vitro fertilisation In vitro fertilisation (IVF) is a process of fertilisation in which an ovum, egg is combined with spermatozoon, sperm in vitro ("in glass"). The process involves monitoring and stimulating the Ovulation cycle, ovulatory process, then removing ...
(IVF), developed by
Patrick Steptoe Patrick Christopher Steptoe CBE FRS (9 June 1913 – 21 March 1988) was an English obstetrician and gynaecologist and a pioneer of fertility treatment. Steptoe was responsible with biologist and physiologist Robert Edwards and the nurse and ...
, Robert Edwards, and
Jean Purdy Jean Marian Purdy (25 April 1945 – 16 March 1985) was a British nurse, embryologist and pioneer of fertility treatment. She was responsible with Robert Edwards and Patrick Steptoe for developing in vitro fertilisation (IVF); Louise Joy Br ...
. Although the media would refer to Brown as a "test tube baby", her conception actually took place in a
Petri dish A Petri dish (alternatively known as a Petri plate or cell-culture dish) is a shallow transparent lidded dish that biologists use to hold growth medium in which cells can be cultured,R. C. Dubey (2014): ''A Textbook Of Biotechnology For Class- ...
. Purdy was the first to see Brown's embryonic cells dividing. Louise Joy Brown was born on 25 July 1978 at
Oldham Oldham is a town in Greater Manchester, England. It lies amongst the Pennines on elevated ground between the rivers River Irk, Irk and River Medlock, Medlock, southeast of Rochdale, and northeast of Manchester. It is the administrative cent ...
's
General Hospital ''General Hospital'' (often abbreviated as ''GH'') is an American daytime television soap opera created by Frank and Doris Hursley which has been broadcast on American Broadcasting Company, ABC since April 1, 1963. Originally a half-hour seria ...
, via a planned
C-section Caesarean section, also known as C-section, cesarean, or caesarean delivery, is the surgical procedure Surgery is a medical specialty that uses manual and instrumental techniques to diagnose or treat pathological conditions (e.g., trauma ...
performed by John Webster. She weighed 5 pounds, 12 ounces (2.608 kg) at birth. In 1982, Brown's sister Natalie was born after also being conceived through IVF, becoming the world's 40th such live birth; in May 1999, Natalie became the first human conceived by IVF to herself give birth, though she did so without IVF. In 2004, Brown married nightclub doorman Wesley Mullinder; Edwards, the only surviving member from the trio who pioneered IVF, attended their wedding. Their first son, conceived naturally, was born on 20 December 2006. She has since had another child. Brown's father died in 2006 at the age of 64,Grady, Denise (23 June 2012)
"Lesley Brown, Mother of World's First 'Test-Tube Baby,' Dies at 64"
''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
''. Retrieved 8 August 2020.
while her mother died in 2012 due to complications from a
gallbladder In vertebrates, the gallbladder, also known as the cholecyst, is a small hollow Organ (anatomy), organ where bile is stored and concentrated before it is released into the small intestine. In humans, the pear-shaped gallbladder lies beneath t ...
infection, also at the age of 64.


Recognition

Brown's birth has been lauded as one of the "most remarkable medical breakthroughs of the 20th century". Edwards was awarded the 2010
Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
in Medicine for this work. In 2022, a plaque was installed on Royal Oldham Hospital to record the importance of Purdy and Sister Muriel Harris to the work.


Ethical and religious issues

Although the Browns knew the procedure was experimental, the doctors did not tell them that no case had yet resulted in a baby, prompting questions of
informed consent Informed consent is an applied ethics principle that a person must have sufficient information and understanding before making decisions about accepting risk. Pertinent information may include risks and benefits of treatments, alternative treatme ...
. In 1978, when asked for his reaction to Brown's birth,
Cardinal Cardinal or The Cardinal most commonly refers to * Cardinalidae, a family of North and South American birds **''Cardinalis'', genus of three species in the family Cardinalidae ***Northern cardinal, ''Cardinalis cardinalis'', the common cardinal of ...
Albino Luciani (who was then the
Patriarch of Venice The Patriarch of Venice (; ) is the ordinary of the Patriarchate of Venice. The bishop is one of only four patriarchs in the Latin Rite of the Catholic Church. The other three are the Patriarch of Lisbon, the Patriarch of the East Indies an ...
and later became
Pope John Paul I Pope John Paul I (born Albino Luciani; 17 October 1912 – 28 September 1978) was head of the Catholic Church and sovereign of the Vatican City State from 26 August 1978 until his death 33 days later. His reign is among the shortest in papal h ...
) expressed concerns about the possibility that artificial insemination could lead to women being used as "baby factories" but also noted that the Browns simply wanted to have a baby and refused to condemn them.


Publications

*


References


External links


BBC profile of Louise Brown (July 2003)

The Lesley Brown Collection
1970 to circa 2015, at Bristol Archives {{DEFAULTSORT:Brown, Louise 1978 births Living people People conceived by in vitro fertilization People from Oldham People from Bristol 20th-century English women 21st-century English women