Lipoblast Features, Annotated
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A lipoblast is a precursor cell for an
adipocyte Adipocytes, also known as lipocytes and fat cells, are the cell (biology), cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through ...
. Alternate terms include adipoblast and preadipocyte. Early stages are almost indistinguishable from
fibroblast A fibroblast is a type of cell (biology), biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework (Stroma (tissue), stroma) for animal Tissue (biology), tissues, and ...
s. File:Lipoblasts and lipocytes.jpg, Lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma File:Dedifferentiated liposarcoma - cropped - very high mag.jpg,
Micrograph A micrograph is an image, captured photographically or digitally, taken through a microscope or similar device to show a magnify, magnified image of an object. This is opposed to a macrograph or photomacrograph, an image which is also taken ...
showing a lipoblast (left-bottom of image) in a liposarcoma.
H&E stain Hematoxylin and eosin stain ( or haematoxylin and eosin stain or hematoxylin–eosin stain; often abbreviated as H&E stain or HE stain) is one of the principal tissue stains used in histology. It is the most widely used stain in medical diag ...
. File:Histopathology of liposarcoma, annotated.jpg, Histopathology of liposarcoma, H&E stain, with the main features: Topic Completed: 1 November 2017. Minor changes: 11 May 2021
- Spindle cells with enlarged, hyperchromatic nuclei.
- Apparently univacuolated adipocytes (may look normal).
- Lipoblasts (multivacuolated), but neither necessary nor sufficient for diagnosis of liposarcoma. File:Histology of a lipoblast-like histiocyte in fat necrosis.jpg, Lipid-laden histiocytes may mimic lipoblasts, but have lightly eosinophilic cytoplasm and a small normochromatic nuclei which are not hollowed out from the lipid vacuoles.Image by Mikael Häggström, MD. Reference for findings:


Liposarcoma

Lipoblasts are seen in liposarcoma and characteristically have abundant multivacuolated clear cytoplasm and a dark staining (hyperchromatic), indented nucleus.


See also

*
Adipogenesis Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as lipoblast ...
* Adipose differentiation-related protein * Lipoblastoma *
List of human cell types derived from the germ layers This is a list of Cell (biology), cells in humans derived from the three embryonic germ layers – ectoderm, mesoderm, and endoderm. Cells derived from ectoderm Surface ectoderm Skin * Trichocyte (human), Trichocyte * Keratinocyte Anterior pi ...


References

Cell biology {{Pathology-stub