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Lexitropsins are members of a family of semi-synthetic 
Recently, carbocyclic derivatives based on
Lexitropsins are members of a family of semi-synthetic DNA
Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
-binding ligand
In coordination chemistry, a ligand is an ion or molecule with a functional group that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's el ...
s. They are structural analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component.
It can ...
s of the natural antibiotics netropsin and distamycin. Antibiotics of this group can bind in the minor groove of DNA with different sequence-selectivity. Lexitropsins form a complexes with DNA with stoichiometry
Stoichiometry () is the relationships between the masses of reactants and Product (chemistry), products before, during, and following chemical reactions.
Stoichiometry is based on the law of conservation of mass; the total mass of reactants must ...
1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity. This property is due to their selectivity towards AT-rich regions.
Recently, carbocyclic derivatives based on pentamidine
Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, '' Balamuthia'' infections, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function. In African trypa ...
were shown to exhibit ''in vivo'' antiproliferative effects on human breast cancer cells, possibly because of their ability to inhibit topoisomerase
DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms, linked (catenated) and unlinked species, and knotted and unknotted DNA. Topological issues in ...
activity.
See also
* Hoechst 33258 *Pentamidine
Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, '' Balamuthia'' infections, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function. In African trypa ...
* DNA binding ligand
* Single-strand binding protein
* Comparison of nucleic acid simulation software
This is a list of notable computer programs that are used for nucleic acid
Nucleic acids are large biomolecules that are crucial in all cells and viruses. They are composed of nucleotides, which are the monomer components: a pentose, 5-carbon su ...
References
{{Reflist Molecular biology DNA-binding substances