LY-334370 is a selective
5-HT1F receptor agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
which was under development by
Eli Lilly and Company
Eli Lilly and Company, Trade name, doing business as Lilly, is an American multinational Medication, pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 count ...
for the treatment of
migraine
Migraine (, ) is a complex neurological disorder characterized by episodes of moderate-to-severe headache, most often unilateral and generally associated with nausea, and light and sound sensitivity. Other characterizing symptoms may includ ...
headaches.
The drug showed efficacy in a phase II clinical trial
but further development was halted due to toxicity detected in animals.
See also
*
CP-135807
CP-135807 is a drug which acts as a potent and selective agonist for the 5-HT1D serotonin receptor, and is used to study the function of this receptor subtype.
See also
* 4-HO-MPMI
* 5-MeO-MPMI
* Eletriptan
Eletriptan, sold under the bra ...
*
Lasmiditan
Lasmiditan, sold under the brand name Reyvow, is a medication used for the acute (active but short-term) treatment of migraine with or without aura (a sensory phenomenon or visual disturbance) in adults. It is not useful for prevention. It is ...
*
SN-22
SN-22 is a chemical compound which acts as a moderately selective agonist at the 5-HT2 family of serotonin receptors, with a Ki of 19 nM at 5-HT2 subtypes versus 514 nM at 5-HT1A receptors. Many related derivatives are known, most of ...
References
External links
*
5-HT1F agonists
Abandoned drugs
Benzamides
Drugs developed by Eli Lilly and Company
4-Fluorophenyl compounds
Piperidinylindoles
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