LY-272,015 is a β-carboline derivative drug developed by

Eli Lilly Eli Lilly (July 8, 1838 – June 6, 1898) was a Union Army officer, pharmacist, chemist, and businessman who founded Eli Lilly and Company. Lilly enlisted in the Union Army during the American Civil War and recruited a company of men to ...

, which acts as a potent and selective

antagonist An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...

5-HT_2B

receptor Receptor may refer to: * Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and respond ...

. It has anti- hypertensive effects in animal models, and is also used in research into the other functions of the 5-HT_2B receptor.

References

5-HT2B antagonists Beta-Carbolines Catechol ethers Drugs developed by Eli Lilly and Company N-Monoalkyltryptamines Phenol ethers {{Nervous-system-drug-stub

See also

References