Kurt Wüthrich (born 4 October 1938 in

Aarberg Aarberg is a List of towns in Switzerland, historic town and a municipalities of Switzerland, municipality in the Seeland (administrative district), Seeland administrative district in the canton of Bern in Switzerland. Aarberg lies from Bern abov ...

Canton of Bern The canton of Bern, or Berne (; ; ; ), is one of the Canton of Switzerland, 26 cantons forming the Switzerland, Swiss Confederation. Its capital city, Bern, is also the ''de facto'' capital of Switzerland. The bear is the heraldic symbol of the c ...

) is a

Swiss Swiss most commonly refers to: * the adjectival form of Switzerland * Swiss people Swiss may also refer to: Places * Swiss, Missouri * Swiss, North Carolina * Swiss, West Virginia * Swiss, Wisconsin Other uses * Swiss Café, an old café located ...

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

and Nobel Chemistry

laureate In English, the word laureate has come to signify eminence or association with literary awards or Military awards and decorations, military glory. It is also used for recipients of the Nobel Prize, the Gandhi Peace Award, the Student Peace Pri ...

, known for developing

nuclear magnetic resonance Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are disturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a ...

(NMR) methods for studying biological

macromolecules A macromolecule is a "molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." Polymers are physi ...

Education and early life

Born in

Switzerland Switzerland, officially the Swiss Confederation, is a landlocked country located in west-central Europe. It is bordered by Italy to the south, France to the west, Germany to the north, and Austria and Liechtenstein to the east. Switzerland ...

, Wüthrich was educated in

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...

physics Physics is the scientific study of matter, its Elementary particle, fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge whi ...

, and

mathematics Mathematics is a field of study that discovers and organizes methods, Mathematical theory, theories and theorems that are developed and Mathematical proof, proved for the needs of empirical sciences and mathematics itself. There are many ar ...

at the

University of Bern The University of Bern (, , ) is a public university, public research university in the Switzerland, Swiss capital of Bern. It was founded in 1834. It is regulated and financed by the canton of Bern. It is a comprehensive university offering a br ...

before pursuing his

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

supervised by Silvio Fallab at the

University of Basel The University of Basel (Latin: ''Universitas Basiliensis''; German: ''Universität Basel'') is a public research university in Basel, Switzerland. Founded on 4 April 1460, it is Switzerland's oldest university and among the world's oldest univ ...

, awarded in 1964.

Career

After his PhD, Wüthrich continued

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary acade ...

with Fallab for a short time before leaving to work at the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...

for two years from 1965 with Robert E. Connick. That was followed by a stint working with Robert G. Shulman at the

Bell Telephone Laboratories Nokia Bell Labs, commonly referred to as ''Bell Labs'', is an American industrial research and development company owned by Finnish technology company Nokia. With headquarters located in Murray Hill, New Jersey, Murray Hill, New Jersey, the compa ...

Murray Hill, New Jersey Murray Hill is an unincorporated community located within portions of both Berkeley Heights and New Providence, located in Union County, in the northern portion of the U.S. state of New Jersey. It is the longtime central location of Bell ...

from 1967 to 1969. Wüthrich returned to Switzerland, to

Zürich Zurich (; ) is the list of cities in Switzerland, largest city in Switzerland and the capital of the canton of Zurich. It is in north-central Switzerland, at the northwestern tip of Lake Zurich. , the municipality had 448,664 inhabitants. The ...

, in 1969, where he began his career there at the

ETH Zürich ETH Zurich (; ) is a public university in Zurich, Switzerland. Founded in 1854 with the stated mission to educate engineers and scientists, the university focuses primarily on science, technology, engineering, and mathematics. ETH Zurich ra ...

, rising to Professor of Biophysics by 1980. He currently maintains a laboratory at the

, at

The Scripps Research Institute Scripps Research is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, tec ...

, in

La Jolla, California La Jolla ( , ) is a hilly, seaside neighborhood in San Diego, California, occupying of curving coastline along the Pacific Ocean. The population reported in the 2010 census was 46,781. The climate is mild, with an average daily temperature o ...

and at the of ShanghaiTech University. He has also been a visiting professor at the

University of Edinburgh The University of Edinburgh (, ; abbreviated as ''Edin.'' in Post-nominal letters, post-nominals) is a Public university, public research university based in Edinburgh, Scotland. Founded by the City of Edinburgh Council, town council under th ...

(1997–2000), the

Chinese University of Hong Kong The Chinese University of Hong Kong (CUHK) is a public university, public research university in Sha Tin, New Territories, Hong Kong. Established in 1963 as a federation of three university college, collegesChung Chi College, New Asia Coll ...

(where he was an Honorary Professor) and

Yonsei University Yonsei University () is a Private university, private Christian university, Christian research university located in Seoul, South Korea. Yonsei is one of the three most prestigious universities in the country, part of a group referred to as SK ...

. During his graduate studies Wüthrich started out working with

electron paramagnetic resonance Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials that have unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but the spin ...

spectroscopy, and the subject of his PhD thesis was "the

catalytic Catalysis () is the increase in reaction rate, rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst ...

activity of

copper Copper is a chemical element; it has symbol Cu (from Latin ) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pinkish-orang ...

compounds in autoxidation reactions". During his time as a postdoc in Berkeley he began working with the newly developed and related technique of

nuclear magnetic resonance spectroscopy Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a Spectroscopy, spectroscopic technique based on re-orientation of Atomic nucleus, atomic nuclei with non-zero nuclear sp ...

to study the hydration of metal complexes. When Wüthrich joined the Bell Labs, he was put in charge of one of the first

superconducting Superconductivity is a set of physical properties observed in superconductors: materials where electrical resistance vanishes and magnetic fields are expelled from the material. Unlike an ordinary metallic conductor, whose resistance decreases g ...

NMR spectrometers, and started studying the structure and dynamics of proteins. He has pursued this line of research ever since. After returning to Switzerland, Wüthrich collaborated with, among others, Nobel laureate Richard R. Ernst on developing the first two-dimensional NMR experiments, and established the nuclear Overhauser effect as a convenient way of measuring distances within

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

s. This research later led to the complete assignment of resonances for among others the bovine pancreatic trypsin inhibitor and

glucagon Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises the concentration of glucose and fatty acids in the bloodstream and is considered to be the main catabolic hormone of the body. It is also used as a Glucagon (medic ...

. In October 2010, Wüthrich participated in the

USA Science and Engineering Festival The USA Science & Engineering Festival is a bi-annual science festival held in Washington, D.C. Founded in 2010 by Larry Bock, the festival is the largest celebration of science, technology, engineering, and mathematics (STEM) disciplines in the U ...

's Lunch with a Laureate program where middle and high school students will get to engage in an informal conversation with a Nobel Prize–winning scientist over a brown-bag lunch. Wüthrich is also a member on the

's Advisory Board and a supporter of the Campaign for the Establishment of a United Nations Parliamentary Assembly, an organisation which campaigns for democratic reform in the United Nations. Wüthrich is a member of the Executive Advisory Board of the World.Minds Foundation, where he contributes to international dialogue on science, research, and innovation policy.

Awards and honors

He was awarded the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

from

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

in 1991, the

Louis-Jeantet Prize for Medicine Established in 1986, the Louis-Jeantet Prizes are funded by the Louis-Jeantet Foundation, ''Fondation Louis-Jeantet'' and awarded each year to experienced researchers who have distinguished themselves in the field of biomedical research in one ...

in 1993, the Otto Warburg Medal in 1999 and half of the

Nobel Prize in Chemistry The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outst ...

in 2002 for "his development of

spectroscopy Spectroscopy is the field of study that measures and interprets electromagnetic spectra. In narrower contexts, spectroscopy is the precise study of color as generalized from visible light to all bands of the electromagnetic spectrum. Spectro ...

for determining the three-dimensional structure of biological macromolecules in solution". He received the Bijvoet Medal of the Bijvoet Center for Biomolecular Research of

Utrecht University Utrecht University (UU; , formerly ''Rijksuniversiteit Utrecht'') is a public university, public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2023, it had an enrollment of ...

in 2008. He was elected a Foreign Member of the Royal Society (ForMemRS) in 2010. He was also awarded the 2018 Fray International Sustainability Award at SIPS 2018 by FLOGEN Star Outreach.

Personal details

On 2 April 2018, Dr. Wüthrich established permanent residency in

Shanghai, China Shanghai, Shanghainese: , Standard Chinese pronunciation: is a direct-administered municipality and the most populous urban area in China. The city is located on the Chinese shoreline on the southern estuary of the Yangtze River, with the ...

, after obtaining a Chinese permanent residence card.

Bibliography

* ''NMR in Biological Research: Peptides and Proteins'', American Elsevier Pub. Co, 1976 * ''NMR of proteins and nucleic acids'', Wiley, 1986 * ''NMR In Structural Biology: A Collection Of Papers By Kurt Wuthrich'', World Scientific Publishing Co Pte Ltd, 1995

References

External links

* including the Nobel Lecture ''NMR Studies of Structure and Function of Biological Macromolecules'' {{DEFAULTSORT:Wuthrich, Kurt 1938 births Living people People from Aarberg Academic staff of ETH Zurich Duke University faculty Academics of the University of Edinburgh Nobel laureates in Chemistry Nuclear magnetic resonance Swiss chemists Swiss biophysicists Swiss Nobel laureates Swiss Protestants Scripps Research faculty Members of the European Molecular Biology Organization Foreign associates of the National Academy of Sciences Members of the French Academy of Sciences Foreign members of the Royal Society Foreign fellows of the Indian National Science Academy Bijvoet Medal recipients Kyoto laureates in Advanced Technology University of Bern alumni