Kirksville is an

unincorporated community An unincorporated area is a parcel of land that is not governed by a local general-purpose municipal corporation. (At p. 178.) They may be governed or serviced by an encompassing unit (such as a county) or another branch of the state (such as th ...

located in Madison County,

Kentucky Kentucky (, ), officially the Commonwealth of Kentucky, is a landlocked U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders Illinois, Indiana, and Ohio to the north, West Virginia to the ...

, United States. It was formerly known as Centerville; the new name honored local store owner Samuel Kirkendall.Rennick, Robert. ''Kentucky Place Names''
p. 161
University Press of Kentucky (Lexington), 1987. Accessed 1 August 2013. It is located at the junction of Kentucky Route 595 and Kentucky Route 1295.

References

Unincorporated communities in Madison County, Kentucky Unincorporated communities in Kentucky {{MadisonCountyKY-geo-stub