Karl Gottfried Paul Döhle (6 June 1855 – 7 December 1928) was a German pathologist who was a native of

Mühlhausen Mühlhausen () is a town in the north-west of Thuringia, Germany, north of Niederdorla, the country's Central Germany (geography)#Geographical centre, geographical centre, north-west of Erfurt, east of Kassel and south-east of Göttingen ...

. He was a student at

Tübingen Tübingen (; ) is a traditional college town, university city in central Baden-Württemberg, Germany. It is situated south of the state capital, Stuttgart, and developed on both sides of the Neckar and Ammer (Neckar), Ammer rivers. about one in ...

Leipzig Leipzig (, ; ; Upper Saxon: ; ) is the most populous city in the States of Germany, German state of Saxony. The city has a population of 628,718 inhabitants as of 2023. It is the List of cities in Germany by population, eighth-largest city in Ge ...

Strassburg Strasbourg ( , ; ; ) is the Prefectures in France, prefecture and largest city of the Grand Est Regions of France, region of Geography of France, eastern France, in the historic region of Alsace. It is the prefecture of the Bas-Rhin Departmen ...

and

Kiel Kiel ( ; ) is the capital and most populous city in the northern Germany, German state of Schleswig-Holstein. With a population of around 250,000, it is Germany's largest city on the Baltic Sea. It is located on the Kieler Förde inlet of the Ba ...

, where he received his doctorate in 1882. Afterwards he was an assistant at the pathological institute in Kiel, where in 1908 he was appointed head of the pathological institute. In 1921 he attained the title of ''professor ordinarius'' (full professor) at the

University of Kiel Kiel University, officially the Christian Albrecht University of Kiel, (, abbreviated CAU, known informally as Christiana Albertina) is a public research university in the city of Kiel, Germany. It was founded in 1665 as the ''Academia Holsator ...

, retiring a few years later in 1924. Döhle is remembered for his work in the field of

histopathology Histopathology (compound of three Greek words: 'tissue', 'suffering', and '' -logia'' 'study of') is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopatholog ...

, particularly in his research of syphilitic inflammation of the

aorta The aorta ( ; : aortas or aortae) is the main and largest artery in the human body, originating from the Ventricle (heart), left ventricle of the heart, branching upwards immediately after, and extending down to the abdomen, where it splits at ...

. He is credited with providing a clear anatomical understanding of syphilitic aortitis.Biography
@ NDB/ADB Deutsche Biographie A sometimes-used synonym of syphilitic aortitis is "Döhle-Heller aortitis", named after Döhle and Arnold Ludwig Gotthilf Heller (1840-1913), Döhle's mentor in Kiel. He is also known for the discovery of small (1-3 μm in diameter) light blue-gray basophilic

leukocyte White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign entities. White blood cells are genera ...

inclusions in the periphery of

neutrophil Neutrophils are a type of phagocytic white blood cell and part of innate immunity. More specifically, they form the most abundant type of granulocytes and make up 40% to 70% of all white blood cells in humans. Their functions vary in differe ...

s, structures that are known today as " Döhle bodies".

Selected writings

* ''Ein Fall von eigentümlicher Aortenerkrankung bei einem Syphilitischen''. (Treatise on syphilitic aortitis), Kiel, 1885. * ''Vorläufige Mittheilung über Blutbefunde bei Masern'', Zentralblatt für allgemeine Pathologie und pathologische Anatomie,

Jena Jena (; ) is a List of cities and towns in Germany, city in Germany and the second largest city in Thuringia. Together with the nearby cities of Erfurt and Weimar, it forms the central metropolitan area of Thuringia with approximately 500,000 in ...

, 1892, 3: 150-152. - Preliminary communication on "blood findings" in

measles Measles (probably from Middle Dutch or Middle High German ''masel(e)'', meaning "blemish, blood blister") is a highly contagious, Vaccine-preventable diseases, vaccine-preventable infectious disease caused by Measles morbillivirus, measles v ...

. * ''Leukocyteneinschlüsse bei Scharlach'', Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, 1912, 61: 63-68. - Leucocyte inclusions in

scarlet fever Scarlet fever, also known as scarlatina, is an infectious disease caused by ''Streptococcus pyogenes'', a Group A streptococcus (GAS). It most commonly affects children between five and 15 years of age. The signs and symptoms include a sore ...

References

''Karl Gottfried Paul Döhle''
@

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograp ...

{{DEFAULTSORT:Dohle, Karl Gottfried Paul 1855 births 1928 deaths People from Mühlhausen Academic staff of the University of Kiel German histologists German pathologists

Selected writings

See also

References