José Santiago may refer to: * José Santiago (1950s pitcher) (1928–2018), Puerto Rican pitcher in Major League Baseball, 1954–1956 * José Santiago (1960s pitcher) (born 1940), Puerto Rican pitcher in Major League Baseball, 1963–1970 * José Santiago (2000s pitcher) (born 1974), Puerto Rican pitcher in Major League Baseball, 1997–2005 * José Avilés Santiago, Puerto Rican politician; mayor of Moca 2001–2021 * Jose L. Santiago, American politician * José Luis Santiago Vasconcelos (1957–2008), Mexican civil servant killed in an aviation accident * José Turiano Santiago (1875–1942?), Filipino patriot in the 1896 Philippine Revolution

See also