Jones' stain, also Jones stain, is a
methenamine
Methenamine, also known as hexamine or hexamethylenetetramine and sold under the brand names Hiprex, Urex, and Urotropin among others, is a urinary tract antiseptic and antibacterial medication which is used in the prevention of recurrent urin ...
silver–
periodic acid
Periodic acid ( ) is an oxoacid of iodine. It can exist in two forms: orthoperiodic acid, with the chemical formula , and metaperiodic acid, which has the formula . Periodic acids are colourless crystals. Periodic acid features iodine in the hig ...
–Schiff stain used in
pathology
Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...
.
It is also referred to as methenamine PAS which is commonly abbreviated MPAS.
It stains for
basement membrane
The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. The basement membrane sits between epithelial tis ...
and is widely used in the investigation of medical
kidney diseases
Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can ...
.
The Jones stain demonstrates the spiked
GBM, caused by subepithelial deposits, seen in
membranous nephropathy
Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly people between ages of 30 and 50 years, usually white people (i.e., those of European, Middle Eastern, or North African ancestry.).
It is the sec ...
.
See also
*
Staining
Staining is a technique used to enhance contrast in samples, generally at the Microscope, microscopic level. Stains and dyes are frequently used in histology (microscopic study of biological tissue (biology), tissues), in cytology (microscopic ...
References
{{Pathology-stub
Staining