Clergymen
* James O'Reilly (priest) (1836–1887), American Roman Catholic priest * James O'Reilly (bishop) (1855–1934), American Roman Catholic bishop of Fargo, 1909–1934Public officials
* James O'Reilly (Canadian politician) (1823–1875), Ontario lawyer and MP * James Edwin O'Reilly (1833–1907), Canadian mayor of Hamilton, Ontario * James O'Reilly (Irish politician) (1916–1992), Northern Irish nationalist * James O'Reilly (judge) (born 1955), Canadian lawyer and Federal judgeSportsmen
* Jamie O'Reilly (born 1988), Irish Gaelic footballer * James O'Reilly (rugby union) (born 1994), New Zealand hookerSee also
* James Reilly (disambiguation) * James Riley (disambiguation) {{hndis, Oreilly, James